The tumorigenicity of mutagenic contact-sensitizing chemicals
| Autor: | Philip S. Magee, Roy E. Albert |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Contact sensitization
Chemistry Carcinogenicity Tests Mutagenicity Tests food and beverages medicine.disease Risk Assessment Toxicology Structure-Activity Relationship Physiology (medical) Dermatitis Allergic Contact Cancer research medicine Carcinogens Animals Humans Safety Risk Reliability and Quality Allergic contact dermatitis Carcinogen Mutagens |
| Zdroj: | Risk analysis : an official publication of the Society for Risk Analysis. 20(3) |
| ISSN: | 0272-4332 |
| Popis: | The electrophilic nature of some contact sensitizers, that is, chemicals that cause allergic contact dermatitis (ACD), is also characteristic of genotoxic tumorigens. Electrophiles can adduct protein, which is the basis for ACD, as well as DNA, which is the basis for mutagenicity and carcinogenicity. This suggests that some electrophilic contact sensitizers may be genotoxic tumorigens. To further investigate this matter, we evaluated 146 chemicals that had been bioassayed for tumorigenicity and mutagenicity in the National Toxicology Program, with an analysis of structure-activity relationships for contact sensitization. Using the data from this analysis and from other sources, the proportion of the contact sensitizers that were both mutagenic and tumorigenic was found to range from 20% to 28%. This finding suggests that there may be in the order of 90 genotoxic tumorigens for rodents among the approximately 384 chemicals that have been validated as contact sensitizers for humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|