Validity and Responsiveness of the Patient-reported Outcomes Measurement Information System in Children With Ulcerative Colitis
| Autor: | Courtney M. Mann, Kirsten M Bahnson, Erica J. Brenner, Li Lin, Millie D. Long, Michael D. Kappelman, Camila Reyes, Wenli Chen, Bryce B. Reeve |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Patient-Reported Outcomes Measurement Information System Adolescent Inflammatory bowel disease Article 03 medical and health sciences 0302 clinical medicine Quality of life 030225 pediatrics Internal medicine medicine Humans Patient Reported Outcome Measures Child business.industry Gastroenterology Construct validity medicine.disease Ulcerative colitis Cross-Sectional Studies Clinical research Pediatrics Perinatology and Child Health Cohort Quality of Life Anxiety Colitis Ulcerative Female 030211 gastroenterology & hepatology medicine.symptom business Information Systems |
| Zdroj: | J Pediatr Gastroenterol Nutr |
| ISSN: | 1536-4801 0277-2116 |
| DOI: | 10.1097/mpg.0000000000003101 |
| Popis: | OBJECTIVES Patient-reported outcome measures allow children to directly report on their health and well-being. We assessed the construct validity and responsiveness of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in children and adolescents with ulcerative colitis (UC). METHODS Through the Inflammatory Bowel Disease Partners Kids & Teens' Internet-based cohort, children with UC reported symptoms related to disease activity (Pediatric Ulcerative Colitis Activity Index), IMPACT-III health-related quality of life measure, and 5 PROMIS Pediatric measures (anxiety, depressive symptoms, pain interference, fatigue, and peer relationships). We included participants aged 9 to 17 years and conducted cross-sectional and longitudinal, mixed-linear regression analyses to examine the extent to which PROMIS Pediatric scores are associated with and respond to changes in Pediatric Ulcerative Colitis Activity Index and IMPACT-III. RESULTS We evaluated 91 participants with UC (mean age 13 years, 57% girls). Better PROMIS Pediatric scores were associated with lower disease activity, in both cross-sectional and longitudinal analyses. For a change from moderate/severe to remission, observed effect estimates were -5.1 points for anxiety, -5.0 for depressive symptoms, -14.7 for pain interference, -13.7 for fatigue, and 5.3 for peer relationships (P |
| Databáze: | OpenAIRE |
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