Stromal vascular fraction combined with silicone rubber chamber improves sciatic nerve regeneration in diabetes
| Autor: | Fatemeh Khadir, Negin Sanaei, Masoume Masoumi-Verki, Aram Mokarizadeh, Rahim Mohammadi, Sima Ahsan |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Pathology medicine.medical_specialty Stromal cell medicine.medical_treatment Diabetes Mellitus Experimental Gastrocnemius muscle chemistry.chemical_compound Silicone medicine Animals Orthopedics and Sports Medicine Rats Wistar Saline business.industry Anatomy Stromal vascular fraction Facial nerve Immunohistochemistry Sciatic Nerve Nerve Regeneration Rats Transplantation surgical procedures operative chemistry Silicone Elastomers Surgery Sciatic nerve Stromal Cells business |
| Zdroj: | Chinese journal of traumatology = Zhonghua chuang shang za zhi. 18(4) |
| ISSN: | 1008-1275 |
| Popis: | PURPOSE To study the effects of transplantation of characterized uncultured stromal vascular fraction (SVF) on sciatic nerve regeneration. METHODS A 10-mm sciatic nerve defect was bridged using a silicone conduit filled with SVF. In control group, silicone conduit was filled with phosphate-buffered saline alone. In sham-operated group, the sciatic nerve was only exposed and manipulated. The regenerated nerve fibers were studied 8 and 12 weeks after surgery. RESULTS Behavioral and functional studies confirmed faster recovery of regenerated axons in SVF transplanted animals than in control group (p |
| Databáze: | OpenAIRE |
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