Epigenetic effects of lung cancer predisposing factors impact on clinical diagnosis and prognosis
| Autor: | Athanasios G. Papavassiliou, Christina Piperi, Fotis Vlastos, Nadine Martinet, Elena Farmaki |
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| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Lung Neoplasms
Reviews Biology medicine.disease_cause Epigenesis Genetic medicine Gene silencing risk factors Animals Humans Hormone metabolism Epigenetics Lung cancer Epigenesis Smoking Cancer Cell Biology DNA Methylation medicine.disease Hormones lung cancer Immunology DNA methylation Cancer research Molecular Medicine prognosis Carcinogenesis gene methylation |
| Zdroj: | Journal of Cellular and Molecular Medicine |
| ISSN: | 1582-4934 1582-1838 |
| Popis: | Lung carcinogenesis is a complex process requiring the acquisition of genetic mutations that confer the malignant phenotype as well as epigenetic alterations that may be both manipulated in the course of therapy. Aberrant gene function and transcriptional silencing by CpG island hypermethylation has become a critical component in the initiation and progression of lung cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Human and animal studies have fostered significant advances in elucidating the role of gene-specific methylation in cancer initiation and progression, the modulation of DNA methylation by carcinogen exposure and the ability of pharmacologic agents to reverse promoter hypermethylation, making it an attractive target to pursue for prevention of lung cancer. This review focuses on how lung cancer predisposing factors participate in epigenetic alterations of lung neoplasia, and discusses the growing implications of these alterations for strategies to control cancer. |
| Databáze: | OpenAIRE |
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