Relationship Between Single-Nucleotide Polymorphisms of Tumor Necrosis Factor Alpha, Interleukin-10, Factor II and Factor V with Risk of Inhibitor Development in Patients with Severe Hemophilia A
| Autor: | Maryam Hosseini, Akbar Dorgalaleh, Shadi Tabibian, Ghazaleh Dadashizadeh, Mahmood Shams, Farhad Zaker, Mohammad Reza Keramati, Shaban Alizadeh, Shahrzad Soori |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Single-nucleotide polymorphism Hemophilia A Polymorphism Single Nucleotide Young Adult Isoantibodies Internal medicine medicine Humans In patient Allele Child Genotyping Pharmacology biology Tumor Necrosis Factor-alpha business.industry Factor V Hematology General Medicine Factor ii Interleukin-10 Interleukin 10 Endocrinology Case-Control Studies biology.protein Molecular Medicine Prothrombin Tumor necrosis factor alpha Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular & Hematological Disorders-Drug Targets. 19:228-232 |
| ISSN: | 1871-529X |
| Popis: | Background: About one-fourth of patients with hemophilia A (HA) develop alloantibodies against factor (F) VIII, as the main treatment challenge. Here, we assessed the relationship between interleukin-10 (IL-10), tumor necrosis factor alpha (TNF-α), FII and FV polymorphisms and risk of inhibitor formation in patients with severe HA. Methods: We divided 39 patients with severe HA in two groups of case (n: 19) and control (n: 20). Genotyping was performed by multiplex amplification tetra arms refractory mutation systempolymerase chain reaction (ARMS-PCR) and PCR-restriction fragment-length polymorphism (PCR-RFLP). Results: TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor development in codominant and dominant inheritance pattern. Moreover, TNFα rs1800629 A allele, decrease the risk of inhibitor formation, while IL10 rs1800896 A>G, FV rs6025 G>A, and FII rs1799963 G>A polymorphisms were not associated with risk of inhibitor development. Conclusion: It seems that TNFα rs1800629 G>A polymorphism decreased the risk of inhibitor formation in Iranian patients with HA. |
| Databáze: | OpenAIRE |
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