Satiety Hormone and Metabolomic Response to an Intermittent High Energy Diet Differs in Rats Consuming Long-Term Diets High in Protein or Prebiotic Fiber
| Autor: | Rustem Shaykhutdinov, Lindsay K. Eller, Alannah D. Maurer, Raylene A. Reimer, Megan C. Hallam, Hans J. Vogel, Aalim M. Weljie |
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| Rok vydání: | 2012 |
| Předmět: |
Blood Glucose
Dietary Fiber Leptin Male obesity medicine.medical_treatment Gene Expression Gut flora Satiety Response Biochemistry 0302 clinical medicine Glucagon-Like Peptide 1 Insulin 2. Zero hunger adiposity 0303 health sciences Glucagon-like peptide-1 Ghrelin Islet Amyloid Polypeptide Postprandial Area Under Curve prebiotic Body Composition Metabolome Female Dietary Proteins medicine.medical_specialty Colon 030209 endocrinology & metabolism Biology Diet High-Fat Article 03 medical and health sciences Internal medicine medicine Animals Weaning metabonomics Peptide YY Rats Wistar 030304 developmental biology Appetite Regulation Prebiotic Feeding Behavior General Chemistry Glucose Tolerance Test biology.organism_classification Rats nuclear magnetic resonance Prebiotics Endocrinology Energy Intake |
| Zdroj: | Journal of Proteome Research |
| ISSN: | 1535-3907 1535-3893 |
| DOI: | 10.1021/pr300487s |
| Popis: | Large differences in the composition of diet between early development and adulthood can have detrimental effects on obesity risk. We examined the effects of an intermittent high fat/sucrose diet (HFS) on satiety hormone and serum metabolite response in disparate diets. Wistar rat pups were fed control (C), high prebiotic fiber (HF) or high protein (HP) diets (weaning to 16 weeks), HFS diet challenged (6 weeks), and finally reverted to their respective C, HF, or HP diet (4 weeks). At conclusion, measurement of body composition and satiety hormones was accompanied by 1H NMR metabolic profiles in fasted and postprandial states. Metabolomic profiling predicted dietary source with >90% accuracy. The HF group was characterized by lowest body weight and body fat (P < 0.05) and increased satiety hormone levels (glucagon-like peptide 1 and peptide-YY). Regularized modeling confirmed that the HF diet is associated with higher gut hormone secretion that could reflect the known effects of prebiotics on gut microbiota and their fementative end products, the short chain fatty acids. Rats reared on a HF diet appear to experience fewer adverse effects from an intermittent high fat diet in adulthood when rematched to their postnatal diet. Metabolite profiles associated with the diets provide a distinct biochemical signature of their effects. |
| Databáze: | OpenAIRE |
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