A nanoscale redox-active composite as a low-fouling interface for capacitive assaying
| Autor: | Paulo Roberto Bueno, Juliana R. Andrade, Flávio C. Bedatty Fernandes |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
Materials science
Immittance function electro-analysis Capacitive sensing Composite number Nanoscale composite Nanotechnology 02 engineering and technology 010402 general chemistry Methacrylate 01 natural sciences law.invention law Monolayer Materials Chemistry Zwitterionic compound Electrical and Electronic Engineering Instrumentation Low-fouling Graphene Metals and Alloys 021001 nanoscience & nanotechnology Condensed Matter Physics 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Electrode Surface modification 0210 nano-technology Electrochemical impedance spectroscopy Biosensor |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0925-4005 |
| DOI: | 10.1016/j.snb.2019.01.164 |
| Popis: | Made available in DSpace on 2019-10-06T17:02:39Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-15 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Royal Society An electro-active nanoscale composite was engineered to serve as an alternative to monolayers in a capacitive biosensing platform. An electrochemical impedance-derived spectroscopic method was applied to analyse the response of this nanoscale (c.a. 9 nm thickness) composite to detect C-reactive protein. The composite was successfully assembled over a conductive electrode and built up by conjugating graphene oxide sheets into a self-assembled 11-ferrocenyl-undecanethiol structure, forming a molecular composite concomitantly coated with zwitterionic methacrylate-based monomers that served as the non-fouling component of the composite. Finally, the functionalization of a composite with receptors allowed the successful testing of its electro-analytical ability to detect C-reactive protein in both phosphate-buffered saline and neat human serum samples. Instituto de Química Univ. Estadual Paulista (UNESP), Nanobionics Research Group (www.nanobionics.pro.br) CP 355 Instituto de Química Univ. Estadual Paulista (UNESP), Nanobionics Research Group (www.nanobionics.pro.br) CP 355 |
| Databáze: | OpenAIRE |
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