Matrix Metalloproteinase-1 Genotype Contributes to the Risk of Non-solid Tumor in Childhood Leukemia
| Autor: | Shun Ping Cheng, Wen Shin Chang, Yuan Nian Hsu, Da Tian Bau, Chieh Lun Hsiao, Pei Chen Hsu, Chia-Wen Tsai, An-Kuo Chou, Jen Sheng Pei |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Oncology Cancer Research medicine.medical_specialty Genotype Childhood leukemia Taiwan 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Odds Ratio medicine Humans Allele Promoter Regions Genetic Childhood Acute Lymphoblastic Leukemia Genetics business.industry General Medicine Odds ratio Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Confidence interval Leukemia 030104 developmental biology Case-Control Studies Child Preschool 030220 oncology & carcinogenesis Female Matrix Metalloproteinase 1 Age of onset business |
| Zdroj: | Anticancer Research. 36:5127-5132 |
| ISSN: | 1791-7530 0250-7005 |
| DOI: | 10.21873/anticanres.11082 |
| Popis: | AIM Up-regulation of metalloproteinase (MMPs) proteins have been shown in various types of solid cancers and the genotype of MMP1 has been associated with the risk of solid cancers. However, the contribution of MMP1 genotype to leukemia has never been investigated to our knowledge. Therefore, in this study we aimed to evaluate the contribution of the genotypic variants in the promoter region of MMP1 to childhood acute lymphoblastic leukemia (ALL) risk in Taiwan. MATERIALS AND METHODS In this case-control study, 266 patients with childhood ALL and 266 non-cancer controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism methodology. RESULTS The distribution of 2G/2G, 1G/2G and 1G/1G for MMP1 promoter rs1799750 genotype was 49.2%, 39.5% and 11.3% in the childhood ALL group and 36.8%, 43.6% and 19.5% in the non-cancer control group, respectively (p for trend=0.0046), significantly differentially distributed between childhood ALL and control groups. The carrier comparisons in dominant and recessive models also support the findings that 1G appears to be the protective allele in childhood ALL. In genotype and gender interaction analysis, it was found that boys carrying the MMP1 rs1799750 1G/2G or 1G/1G genotypes had lower odds ratios(ORs) of 0.68 and 0.43 [95% confidence intervals (CI)=0.47-0.98 and 0.26-0.73, p=0.0395 and 0.0013, respectively] for childhood ALL than those carrying the 2G/2G genotype. Analysis of genotype inaction with age of onset age showed those aged less than 3.5 years at onset carrying the 1G/2G or 1G/1G genotypes had lower ORs (0.0183 and 0.0004, respectively) for childhood ALL, but there was no such difference for those having an age at onset of 3.5 years or more. CONCLUSION Our results indicate that the MMP1 rs1799750 1G allele is a protective biomarker for childhood ALL. |
| Databáze: | OpenAIRE |
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