Acceleration of BMI in Early Childhood and Risk of Sustained Obesity
Autor: | Mandy Vogel, Tobias Lipek, Ulrike Spielau, Eberhard Keller, Roland Pfäffle, Wieland Kiess, Mandy Geserick, Ruth Gausche, A. Körner |
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Rok vydání: | 2018 |
Předmět: |
Male
Risk Pediatric Obesity Pediatrics medicine.medical_specialty Index (economics) Adolescent Acceleration (differential geometry) 030209 endocrinology & metabolism Weight Gain Body Mass Index 03 medical and health sciences 0302 clinical medicine Reference Values medicine Humans Prospective Studies 030212 general & internal medicine Early childhood Age of Onset Child Prospective cohort study Retrospective Studies business.industry Infant Newborn Recem nascido Infant Retrospective cohort study General Medicine Overweight medicine.disease Obesity Child Preschool Reference values Female Age of onset business Body mass index Demography |
Zdroj: | New England Journal of Medicine. 379:1303-1312 |
ISSN: | 1533-4406 0028-4793 |
Popis: | The dynamics of body-mass index (BMI) in children from birth to adolescence are unclear, and whether susceptibility for the development of sustained obesity occurs at a specific age in children is important to determine.To assess the age at onset of obesity, we performed prospective and retrospective analyses of the course of BMI over time in a population-based sample of 51,505 children for whom sequential anthropometric data were available during childhood (0 to 14 years of age) and adolescence (15 to 18 years of age). In addition, we assessed the dynamics of annual BMI increments, defined as the change in BMI standard-deviation score per year, during childhood in 34,196 children.In retrospective analyses, we found that most of the adolescents with normal weight had always had a normal weight throughout childhood. Approximately half (53%) of the obese adolescents had been overweight or obese from 5 years of age onward, and the BMI standard-deviation score further increased with age. In prospective analyses, we found that almost 90% of the children who were obese at 3 years of age were overweight or obese in adolescence. Among the adolescents who were obese, the greatest acceleration in annual BMI increments had occurred between 2 and 6 years of age, with a further rise in BMI percentile thereafter. High acceleration in annual BMI increments during the preschool years (but not during the school years) was associated with a risk of overweight or obesity in adolescence that was 1.4 times as high as the risk among children who had had stable BMI. The rate of overweight or obesity in adolescence was higher among children who had been large for gestational age at birth (43.7%) than among those who had been at an appropriate weight for gestational age (28.4%) or small for gestational age (27.2%), which corresponded to a risk of adolescent obesity that was 1.55 times as high among those who had been large for gestational age as among the other groups.Among obese adolescents, the most rapid weight gain had occurred between 2 and 6 years of age; most children who were obese at that age were obese in adolescence. (Funded by the German Research Council for the Clinical Research Center "Obesity Mechanisms" and others; ClinicalTrials.gov number, NCT03072537 .). |
Databáze: | OpenAIRE |
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