The Effect of Apple Juice on Antioxidant Enzymes and Lipid Profiles in Orchidectomized Rats
| Autor: | Mahmood Abedinzade, Korosh Khanaki, Katayoon Harialchi, Mojtaba Farahbakhsh, Mahmood Khosravi |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
chemistry.chemical_classification
medicine.medical_specialty Antioxidant biology Cholesterol business.industry medicine.medical_treatment lcsh:R lcsh:Medicine medicine.disease_cause Superoxide dismutase Sham group chemistry.chemical_compound Enzyme Endocrinology chemistry Internal medicine Male rats biology.protein medicine Alkaline phosphatase lipids (amino acids peptides and proteins) business Oxidative stress |
| Zdroj: | Majallah-i taḥqīqāt-i ̒ulūm-i pizishkī-i Zāhidān, Vol 17, Iss 3, Pp 1-4 (2015) |
| ISSN: | 2228-6403 2008-7977 |
| DOI: | 10.17795/zjrms1132 |
| Popis: | Background: The age-dependent worsening of lipid profiles increased the risk of cardiovascular disease in males. Eating fruits and vegetables is known to be beneficial on lipid profile. Objectives: The objective of this research was to delineate whether drinking daily squeezed apple juice (AJ) modulates lipid profile and antioxidant enzymes in the animal model that gonadectomized. Materials and Methods: In this experimental study, 28 male rats were equally divided among the following 4 groups: group I (control), orchidectomized (ORX), ORX +AJ 10%, and ORX+ AJ 25%. After 60 days of drinking AJ, superoxide dismutase (SOD), alkaline phosphatase (ALP), cholesterol, LDL, HDL and triglycerides in serum were evaluated. Data analyzed by SPSS-16 and computed using one way ANOVA followed by Tukey multiple comparison test. P < 0.05 was statistically significant. Results: In the ORX group compared with the sham group serum SOD and ALP activities decreased (P < 0.05), while serum cholesterol, triglycerides, LDL increased but HDL decreased in ORX groups (P < 0.05). In contrast to the ORX group, drinking AJ decreased (P < 0.05) concentration of LDL, TG and cholesterol in the serum. AJ also increased (P < 0.05) serum HDL, SOD and ALP activities compared with the ORX group. Conclusions: Drinking AJ prevented oxidative stress by elevating serum antioxidant enzymes. |
| Databáze: | OpenAIRE |
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