Effect of simvastatin (MK-733) on plasma triacylglycerol levels in rats
| Autor: | Hitoshi Fukuzumi, Kanako Hase, Akiko Sato, Toshio Kamei, Fumiaki Ishida, Keiko Watanabe |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Male
Simvastatin medicine.medical_specialty Lipoproteins Coenzyme A Reductase Biochemistry chemistry.chemical_compound Oral administration Internal medicine polycyclic compounds medicine Animals Clofibrate Lovastatin Triglycerides Pharmacology Lipoprotein lipase biology Triglyceride Chemistry Muscles Body Weight nutritional and metabolic diseases Rats Inbred Strains Organ Size Hydroxymethylglutaryl-CoA reductase Rats Lipoprotein Lipase Endocrinology Adipose Tissue Liver Enzyme inhibitor biology.protein lipids (amino acids peptides and proteins) Energy Intake medicine.drug |
| Zdroj: | Biochemical Pharmacology. 41:1163-1172 |
| ISSN: | 0006-2952 |
| Popis: | The effect of simvastatin (MK-733), an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, on plasma triacylglycerol (TG) levels was studied in rats. Dietary administration of MK-733 (0.055%, w/w) for 7 days significantly (P less than 0.05) reduced plasma TG levels by 30.6% associated with a 44.3% significant (P less than 0.01) reduction in very low density lipoprotein TG (VLDL-TG) as compared to those in the concurrent control rats. Clofibrate (0.08%, w/w) also significantly (P less than 0.05) decreased plasma TG levels by 26.1%. MK-733 did not affect the triacylglycerol secretion rate (TGSR) during 0-1.5 hr after administration of Triton WR-1339, but reduced it by 33.9% during 1.5-3.0 hr. Clofibrate also decreased TGSR during 1.5-3.0 hr. MK-733 increased lipoprotein lipase (LPL) activity in epididymal adipose tissue and thigh muscle by 36.3 and 55.0% respectively. MK-733 significantly (P less than 0.05) increased LPL activity in the post-heparin plasma by 21.5%, although it did not affect hepatic triacylglycerol lipase (H-TGL) activity. Clofibrate did not affect LPL activity in the tissues or LPL and H-TGL activities in the post-heparin plasma. It is considered that the mechanism of plasma TG-lowering effect of MK-733 is the removal of VLDL-TG by an increase in LPL activity in the tissues as well as a decrease in the TGSR. |
| Databáze: | OpenAIRE |
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