A case of marked response to preoperative chemoradiotherapy for rectal cancer with para-aortic lymph node metastasis
| Autor: | Hajime Shibuya, Takuya Akahane, Keiji Matsuda, Atsushi Horiuchi, Ryu Shimada, S. Ishihara, Hideki Yamada, Tamuro Hayama, Keijirou Nozawa, Toshiaki Watanabe |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty Antimetabolites Antineoplastic Bevacizumab Colorectal cancer medicine.medical_treatment Leucovorin Colonoscopy Angiogenesis Inhibitors Antibodies Monoclonal Humanized Preoperative care Metastasis Antineoplastic Combined Chemotherapy Protocols Preoperative Care medicine Humans Neoadjuvant therapy Aged Tegafur Chemotherapy medicine.diagnostic_test business.industry Rectal Neoplasms Radiotherapy Dosage medicine.disease Neoadjuvant Therapy Surgery Carcinoembryonic Antigen Lymphatic Metastasis Camptothecin Radiology Fluorouracil business Tomography X-Ray Computed Chemoradiotherapy medicine.drug |
| Zdroj: | International surgery. 96(2) |
| ISSN: | 0020-8868 |
| Popis: | A 67-year-old man had rectal cancer with para-aortic lymph node metastasis. Prior to surgical resection, tegafur-uracil and leucovorin had been administered orally as chemotherapy, and radiotherapy (50.4 Gy) was applied for the rectum and para-aortic lymph nodes. Low anterior resection was then performed, followed by 45 cycles of chemotherapy in total. Enlargement of the left axillary lymph nodes was noted during treatment, but nodes shrank in response to treatment with bevacizumab + FOLFIRI (i.e., irinotecan + 5-fluorouracil/leucovorin). As of the time of writing, 36 months after diagnosis, no swelling of the para-aortic lymph nodes was evident and chemotherapy was being continued. This patient was alive after achieving response to neoadjuvant therapy comprising chemotherapy and irradiation of the para-aortic lymph nodes, along with postoperative chemotherapy. This therapeutic approach of preoperative chemotherapy plus irradiation of the primary lesion and para-aortic lymph nodes has potential as an effective treatment. |
| Databáze: | OpenAIRE |
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