High Human T-Cell Leukemia Virus Type 1c Proviral Loads Are Associated With Diabetes and Chronic Kidney Disease: Results of a Cross-Sectional Community Survey in Central Australia
| Autor: | Mohammad Radwanur Talukder, Richard Woodman, Hai Pham, Kim Wilson, Antoine Gessain, John Kaldor, Lloyd Einsiedel |
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| Přispěvatelé: | Alice Springs Hospital, Flinders University [Adelaide, Australia], National Serology Reference Laboratory, Epidémiologie et Physiopathologie des Virus Oncogènes / Oncogenic Virus Epidemiology and Pathophysiology (EPVO (UMR_3569 / U-Pasteur_3)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), University of New South Wales [Sydney] (UNSW), This study was funded by the National Health and Medical Research Council (project grant 1088517). |
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: |
Microbiology (medical)
MESH: Humans MESH: Human T-lymphotropic virus 1 MESH: Diabetes Mellitus diabetes [SDV]Life Sciences [q-bio] MESH: Renal Insufficiency Chronic Australia HTLV-1 proviral load MESH: Australia MESH: Adult MESH: Proviruses Infectious Diseases MESH: Cross-Sectional Studies HTLV-1 MESH: HTLV-I Infections MESH: Surveys and Questionnaires MESH: Viral Load chronic kidney disease MESH: Leukemia T-Cell |
| Zdroj: | Clinical Infectious Diseases Clinical Infectious Diseases, 2023, 76 (3), pp.e820-e826. ⟨10.1093/cid/ciac614⟩ |
| ISSN: | 1058-4838 1537-6591 |
| DOI: | 10.1093/cid/ciac614⟩ |
| Popis: | Background A link between chronic inflammation and several noncommunicable diseases (NCDs) has been established. Although chronic infection with the human T-cell leukemia virus type 1 (HTLV-1) is the recognized cause of several inflammatory diseases and these are associated with a high number of HTLV-1–infected cells in peripheral blood (proviral load [PVL]), possible interactions between PVL and NCDs have not been studied at a community level. Methods Adult Aboriginal residents of 7 remote communities were invited to complete a health survey between 25 August 2014 and 30 June 2018. Blood was drawn for HTLV-1 serology and PVL, and relevant medical conditions were obtained from health records. Associations between HTLV-1 PVL and diabetes, chronic kidney disease (CKD), and coronary artery disease (CAD) were determined using logistic regression, adjusting for available confounders. Results Among 510 participants (56% of the estimated adult resident population, 922), 197 (38.6%) were HTLV-1–infected. A high HTLV-1 PVL was associated with a 2-fold increase in the odds of diabetes and CKD (diabetes, adjusted odds ratio [aOR], 1.95; 95% confidence interval [CI], 1.06–3.61; P = .033 and CKD: aOR, 2.00; 95% CI, 1.03–3.8; P = .041). A nonsignificant association between high PVL and CAD (aOR, 7.08; 95% CI, 1.00–50.18; P = .05) was found for participants aged Conclusions In a community-based study in central Australia, people with HTLV-1 who had high HTLV-1 PVL were more likely to have diabetes and CKD. These findings have potential clinical implications. |
| Databáze: | OpenAIRE |
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