The Synthesis and Antimicrobial Activity of Some 4-Hydroxycoumarin Derivatives
| Autor: | Samija Muratović, Selma Spirtović, Davorka Završnik, Marica Medić-Šarić, Dženita Softić |
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| Rok vydání: | 2008 |
| Předmět: |
derivatives of 4-hydroxycoumarin
Staphylococcus Bacillus Microbial Sensitivity Tests medicine.disease_cause Article dimers chemistry.chemical_compound Anti-Infective Agents Tetramer medicine Organic chemistry MIC Escherichia coli Candida lcsh:R5-920 antimicrobial activity Minimum bactericidal concentration biology business.industry 4-Hydroxycoumarins General Medicine Antimicrobial Coumarin biology.organism_classification tetramers chemistry 4-Hydroxycoumarin minimal inhibition concentration Growth inhibition lcsh:Medicine (General) business Bacteria |
| Zdroj: | Bosnian Journal of Basic Medical Sciences, Vol 8, Iss 3 (2008) |
| ISSN: | 1840-4812 1512-8601 |
| DOI: | 10.17305/bjbms.2008.2933 |
| Popis: | Due to exceptional reactivity of 4-hydroxycoumarin, the synthesis of new coumarin derivatives of dimer and tetramer type has been carried out. The synthesis was carried out from 4-hydroxycoumarin and various aromatic aldehydes. In this way, compounds of the dimer 3,3’-(benzilidene)bis (4-hydroxycoumarin) type, as well as of the tetramer 3,3,’3’,’3’’’-(1,4-dim- ethylenphenyl)tetra (4-hydroxycoumarin) type were prepared.The newly synthesized derivatives contain different functional groups, and as such they could exhibit microbiological activity. Therefore, we tested the microbiological activity of these derivatives on various species of bacteria and fungi. The tested compounds have shown different activity in terms of growth inhibition of microorganisms. Newly synthesized derivatives exhibit antibacterial activities, manifested as growth inhibition on Grampositive bacteria types (Bacillus, Staphylococcus), while the activity against Candida was much weaker. The same compound did not show any antimicrobial activity against two Gram-negative bacteria types (Escherichia coli, Pseudomonas aeruginosa). The compound 1 showed the best microbiological activity. The obtained results confirmed its good antibacterial and antimycotic activities against different microorganisms. |
| Databáze: | OpenAIRE |
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