Postnatally Induced Inactivation of gp130 in Mice Results in Neurological, Cardiac, Hematopoietic, Immunological, Hepatic, and Pulmonary Defects
| Autor: | Werner Müller, Maries van den Broek, Tetsuya Taga, Ulrich A. K. Betz, Tadamitsu Kishimoto, Klaus Rajewsky, Wilhelm Bloch, Klaus Addicks, Kanji Yoshida |
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| Přispěvatelé: | University of Zurich |
| Rok vydání: | 1998 |
| Předmět: |
Lipopolysaccharides
Cardiotrophin 1 Hematopoietic System medicine.medical_treatment Immunology 610 Medicine & health Vaccinia virus CD8-Positive T-Lymphocytes Ciliary neurotrophic factor 10263 Institute of Experimental Immunology Cre/loxP technology conditional gene targeting Antibodies Vesicular stomatitis Indiana virus gene targeting gp130-dependent cytokines gp130 Mice Viral Proteins Antigens CD Cytokine Receptor gp130 medicine Animals Immunology and Allergy Peripheral Nerves Receptors Cytokine Lung Recombination Genetic 2403 Immunology Membrane Glycoproteins Integrases biology Histocytochemistry Oncostatin M Interleukin Articles Glycoprotein 130 Listeria monocytogenes Microscopy Electron Cytokine Liver 2723 Immunology and Allergy biology.protein 570 Life sciences Cytokines Cytokine receptor Leukemia inhibitory factor |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.188.10.1955 |
| Popis: | The pleiotrophic but overlapping functions of the cytokine family that includes interleukin (IL)-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin 1 are mediated by the cytokine receptor subunit gp130 as the common signal transducer. Although mice lacking individual members of this family display only mild phenotypes, animals lacking gp130 are not viable. To assess the collective role of this cytokine family, we inducibly inactivated gp130 via Cre-loxP–mediated recombination in vivo. Such conditional mutant mice exhibited neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects, demonstrating the widespread importance of gp130-dependent cytokines. |
| Databáze: | OpenAIRE |
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