Antifibrotic effect of captopril and enalapril on paraquat-induced lung fibrosis in rats
| Autor: | Ebraheim Pour-Esmaeil, Parvin Mokhtary, Ali Mohammadi-Karakani, Mahmoud Ghazi-Khansari, Masoud Sotoudeh, Shirin Maghsoud |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Paraquat medicine.medical_specialty Captopril Time Factors Pulmonary Fibrosis Administration Oral Angiotensin-Converting Enzyme Inhibitors Toxicology Lipid peroxidation Hydroxyproline chemistry.chemical_compound Enalapril Internal medicine Pulmonary fibrosis medicine Animals cardiovascular diseases Rats Wistar Lung Dose-Response Relationship Drug biology Herbicides medicine.disease Glutathione Rats Pulmonary Alveoli Treatment Outcome medicine.anatomical_structure Endocrinology chemistry Enzyme inhibitor ACE inhibitor biology.protein Collagen Lipid Peroxidation Injections Intraperitoneal hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Journal of Applied Toxicology. 27:342-349 |
| ISSN: | 1099-1263 0260-437X |
| DOI: | 10.1002/jat.1212 |
| Popis: | Although different treatment modalities have been implemented for pulmonary fibrosis, the results have not been promising and these conditions have been considered untreatable and irreversible. Thus, a plethora of new drugs has been tried for the control of this condition in recent years. This study examined the effects of two angiotensin-converting enzyme inhibitors, captopril and enalapril, on paraquat-induced pulmonary fibrosis in rats, through biochemical and histopathological parameters. Male albino Wistar rats were divided into eight groups (n = 4-5 each), including control, paraquat, captopril alone, captopril treatment and pre-treatment, enalapril alone, enalapril treatment and pre-treatment. After 21 days of treatment, the lungs were removed and the levels of hydroxyproline, glutathione and lipid peroxidation were determined. Angiotensin-converting enzyme inhibitors showed no effect on glutathione and lipid peroxidation. The results also demonstrated that captopril and enalapril improved pulmonary fibrosis as shown by histopathology, as well as a decreased content of hydroxyproline (P < 0.001) in the lung tissue. In conclusion, the present findings suggest that the antifibrotic effect of these drugs may be related to the inhibition of angiotensin-converting enzyme. |
| Databáze: | OpenAIRE |
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