Respiratory response of guinea pigs to ozone alone and with sulfur dioxide
| Autor: | M O, Amdur, V, Ugro, D W, Underhill |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Ozone
Lung Respiration Guinea Pigs Public Health Environmental and Occupational Health Sulfuric acid Respiratory Function Tests Guinea pig chemistry.chemical_compound medicine.anatomical_structure chemistry Biochemistry Environmental chemistry medicine Bioassay Animals Sulfur Dioxide Drug Interactions Sulfur dioxide Respiratory tract |
| Zdroj: | American Industrial Hygiene Association journal. 39(12) |
| ISSN: | 0002-8894 |
| Popis: | This study was designed to utilize our guinea pig bioassay method for irritant response to address the question of whether or not ozone and sulfur dioxide appeared to react to form sulfuric acid in the respiratory tract. Animals were exposed to 0.2, 0.4, and 0.8 ppm of each gas alone and to the combination at concentrations of 0.4 and 0.8 ppm. In these experiments sulfur dioxide alone produced no statistically significant alterations in respiration. All concentrations of ozone produced an increase in respiratory frequency. At the two higher concentrations the increase in frequency was accompanied by a decrease in compliance. The response to the combinations was the same as the response to those levels of ozone alone. No sulfuric acid was detected in the chamber atmosphere. The biological data suggest that none was formed in the lung. |
| Databáze: | OpenAIRE |
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