Acute and Late Toxicity after Moderate Hypofractionation with Simultaneous Integrated Boost (SIB) Radiation Therapy for Prostate Cancer. A Single Institution, Prospective Study
| Autor: | László Gesztesi, András Herein, Tibor Major, Kliton Jorgo, Tamás Pócza, Csaba Polgár, Péter Ágoston, Gábor Stelczer |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Simultaneous integrated boost Cancer Research medicine.medical_specialty Intensity-modulated radiotherapy medicine.medical_treatment Urology Image-guided radiotherapy Whole-Pelvis Pathology and Forensic Medicine 03 medical and health sciences Prostate cancer 0302 clinical medicine Moderate hypofractionation Prostate medicine Humans Radiation Injuries Prospective cohort study Aged Aged 80 and over Genitourinary system business.industry Prostatic Neoplasms General Medicine Middle Aged medicine.disease Radiation therapy 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Toxicity Radiation Dose Hypofractionation Original Article Radiotherapy Intensity-Modulated business |
| Zdroj: | Pathology Oncology Research |
| ISSN: | 1532-2807 1219-4956 |
| DOI: | 10.1007/s12253-019-00623-2 |
| Popis: | Asbtract To evaluate the acute and late toxicity using moderately hypofractionated, intensity-modulated radiotherapy (IMRT) with a simultaneous integrated boost (SIB) to prostate for patients with intermediate and high risk prostate cancer. From 2015 to 2017, 162 patients were treated with IMRT with SIB to the prostate. IMRT plans were designed to deliver 50.4Gy in 28 fractions (1.8 Gy/fraction) to the pelvic lymph nodes (whole pelvis radiotherapy, WPRT) while simultaneously delivering 57.4 Gy in 28 fractions (2.05 Gy/fraction) to the seminal vesicles and 70 Gy in 28 fractions (2.5 Gy/fraction) to the prostate for high risk patients. For intermediate risk patients the same technique was applied, without WPRT. Acute and cumulative late genitourinary (GU) and gastrointestinal (GI) toxicities were scored according to the Radiation Therapy Oncology Group (RTOG) scoring system. Of the 162 patients enrolled, 156 (96%) completed the treatment as planned. The median follow-up time was 30 months. Seventy-eight patients (48.2%) were treated with WPRT. The rate of acute grade ≥ 2 GI and GU toxicities in all patients were 22% and 58%, respectively. The rate of cumulative late grade ≥ 2 GI and GU toxicities were 11% and 17%, respectively. Acute grade 3 GI and GU toxicities occurred in 1% and 1%. Late grade 3 GI and GU side effects occurred in 5% and 4%, respectively. None of the patients developed grade ≥ 4 toxicity. IMRT with SIB technique using moderate hypofractionation to the prostate is feasible treatment option for intermediate and high risk patients, associated with low rate of severe GU and GI toxicities. |
| Databáze: | OpenAIRE |
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