Co-expression Network Analysis Reveals Novel Genes Underlying Alzheimer’s Disease Pathogenesis
| Autor: | Yi-xin Yin, Shao-dan Zhou, Hai-peng Lu, Rui-guang Hu, Rui-ting Hu, Bang-li Hu, Qian Yu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Aging Cognitive Neuroscience NEFM Disease Computational biology Disease pathogenesis Biology lcsh:RC321-571 Novel gene Pathogenesis 03 medical and health sciences 0302 clinical medicine microRNA Alzeheimer’s disease gene Gene lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Original Research miRNA expreesion pathway 030104 developmental biology Gene Enrichment 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | Frontiers in Aging Neuroscience, Vol 12 (2020) Frontiers in Aging Neuroscience |
| ISSN: | 1663-4365 |
| DOI: | 10.3389/fnagi.2020.605961/full |
| Popis: | Background: The pathogenesis of Alzheimer’s disease (AD) remains to be elucidated. This study aimed to identify the hub genes in AD pathogenesis and determine their functions and pathways.Methods: A co-expression network for an AD gene dataset with 401 samples was constructed, and the AD status-related genes were screened. The hub genes of the network were identified and validated by an independent cohort. The functional pathways of hub genes were analyzed.Results: The co-expression network revealed a module that related to the AD status, and 101 status-related genes were screened from the trait-related module. Gene enrichment analysis indicated that these status-related genes are involved in synaptic processes and pathways. Four hub genes (ENO2, ELAVL4, SNAP91, and NEFM) were identified from the module, and these hub genes all participated in AD-related pathways, but the associations of each gene with clinical features were variable. An independent dataset confirmed the different expression of hub genes between AD and controls.Conclusions: Four novel genes associated with AD pathogenesis were identified and validated, which provided novel therapeutic targets for AD. |
| Databáze: | OpenAIRE |
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