Estimation of Extracellular Volume by a Two-Frequency Measurement

Autor: H. G. Goovaerts, Robert M. Heethaar, M. ten Bolscher, Th. J. C. Faes, J. C. Netelenbosch, G. W. de Valk-de Roo, W.J.F. van der Vijgh
Rok vydání: 1999
Předmět:
Zdroj: Annals of the New York Academy of Sciences. 873:99-104
ISSN: 1749-6632
0077-8923
DOI: 10.1111/j.1749-6632.1999.tb09455.x
Popis: An approach to determine intra- and extracellular conduction on the basis of Bode analysis is presented. Estimation of the ratio between intra- and extracellular conduction could be performed by phase measurement only, midrange in the bandwidth of interest. An important feature is that the relation between intra- and extracellular conduction can be continuously monitored by phase measurement and no curve fitting whatsoever is required. Based on a two-frequency measurement determining Re at 4 kHz and phi max at 64 kHz, it proved possible to estimate extracellular volume (ECV) in 23 patients. Reference values on ECV were determined by sodium bromide. The results show a good correlation (r = 0.90) with the reference method. The average error of ECV estimation was -3.6% (SD 8.4).
Databáze: OpenAIRE