Identification of a casein kinase II phosphorylation domain in NS1 protein of H5N1 influenza virus
| Autor: | Asad U. Khan, Tamanna Anwar |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Infectivity
amino acid (AA) Mutation business.industry General Medicine Hypothesis medicine.disease_cause Virology Influenza A virus subtype H5N1 Virus nonstructural protein 1 (NS1) casein kinase II (CKII) phosphorylation Influenza A virus Medicine Phosphorylation mutation Casein kinase 2 business Protein secondary structure |
| Zdroj: | Bioinformation |
| ISSN: | 0973-2063 0973-8894 |
| DOI: | 10.6026/97320630002057 |
| Popis: | Influenza virus causes febrile respiratory illness. The infection results in significant mortality, morbidity and economic disruption. In this bioinformatics study, we used the NS1 (the conserved nonstructural) protein of influenza A virus to demonstrate its role in infectivity. Our in silico study revealed a new Casein kinase II (CKII) phosphorylation domain at position 151-154. This domain was formed due to the mutation at position 151 (T151I). Moreover, considerable difference in the secondary structure of this protein due to mutation was also reported. It is also confirmed by contact residue analysis that the changes in secondary structure are due to mutations. |
| Databáze: | OpenAIRE |
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