Glioma stem-like cells and metabolism:Potential for novel therapeutic strategies
| Autor: | Xia Liu, M. Carmen Galan, Abigail Harland, Mattia Ghirardello, Kathreena M Kurian, Claire M Perks |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
glioma stem-like cell
Cancer Research endocrine system Population Metabolic reprogramming cancer metabolism Review Biology cancer stem cell (CSC) Therapeutic approach Cancer stem cell Glioma medicine metabolic reprogramming education therapeutic strategies RC254-282 education.field_of_study fungi Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease Oncology Cancer metabolism Cancer research ICEP Reprogramming Function (biology) |
| Zdroj: | Harland, A J, Liu, X, Ghirardello, M, Galan, M C, Perks, C M & Kurian, K M 2021, ' Glioma stem-like cells and metabolism : Potential for novel therapeutic strategies ', Frontiers in Oncology, vol. 11, 743814 . https://doi.org/10.3389/fonc.2021.743814 Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| DOI: | 10.3389/fonc.2021.743814 |
| Popis: | Glioma stem-like cells (GSCs) were first described as a population which may in part be resistant to traditional chemotherapeutic therapies and responsible for tumour regrowth. Knowledge of the underlying metabolic complexity governing GSC growth and function may point to potential differences between GSCs and the tumour bulk which could be harnessed clinically. There is an increasing interest in the direct/indirect targeting or reprogramming of GSC metabolism as a potential novel therapeutic approach in the adjuvant or recurrent setting to help overcome resistance which may be mediated by GSCs. In this review we will discuss stem-like models, interaction between metabolism and GSCs, and potential current and future strategies for overcoming GSC resistance. |
| Databáze: | OpenAIRE |
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