Efficacy and Safety of Mechanical Thrombectomy in Older Adults with Acute Ischemic Stoke

Autor: Alessandro Davoli, Marina Diomedi, Fana Alemseged, Domenico Samà, Simone Napolitano, Fabrizio Sallustio, Vittoria Carla D'Agostino, Daniel Konda, Giacomo Koch, Caterina Motta, Enrico Pampana, Roberto Gandini, Roberto Floris, Daniele Morosetti
Jazyk: angličtina
Rok vydání: 2017
Předmět:
Male
medicine.medical_specialty
medicine.medical_treatment
Tissue plasminogen activator
elderly
NO
Brain Ischemia
Brain ischemia
03 medical and health sciences
ischemic stroke
mechanical thrombectomy
outcome
0302 clinical medicine
Internal medicine
medicine
Humans
030212 general & internal medicine
Stroke
Retrospective Studies
Thrombectomy
Aged
80 and over
business.industry
Endovascular Procedures
Settore MED/37 - Neuroradiologia
Retrospective cohort study
Thrombolysis
Odds ratio
Middle Aged
medicine.disease
elderly
ischemic stroke
mechanical thrombectomy
outcome
Brain Ischemia
Endovascular Procedures
Retrospective Studies
Treatment Outcome
Confidence interval
Surgery
Mechanical thrombectomy
Treatment Outcome
Italy
Female
Settore MED/26 - Neurologia
Geriatrics and Gerontology
business
030217 neurology & neurosurgery
medicine.drug
Popis: Objectives To evaluate the safety and efficacy of endovascular therapy in elderly adults treated for acute ischemic stroke. Design Retrospective cohort study. Setting Comprehensive Stroke Center, University of Tor Vergata, Rome, Italy. Participants Elderly adults treated for acute ischemic stroke (N = 219). Measurements Participants were divided into two groups based on their age (n = 62, ≥80; n = 157, .99) or symptomatic (11% vs 14%, P = .6) ICH, or mortality (40.3% vs 29.2%, P = .14). Multivariable analysis revealed that, in the older group, onset National Institute of Health Stroke Scale (NIHSS) score (odds ratio (OR) = 0.65, 95% confidence interval (CI) = 0.44–0.96, P = .03) and 24-hour clinical improvement (OR = 141.13, 95% CI = 2.96–6,720.7, P = .01) were independent predictors of 3-month functional independence. Conclusion These findings suggest that endovascular treatment for stroke in selected elderly adults could be safe and effective. Major determinants of outcome in this subgroup of elderly patients are presentation NIHSS score and 24-hour clinical improvement.
Databáze: OpenAIRE
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