Expression of IL-15 and IL-15 Receptor Isoforms in Select Structures of Human Fetal Brain
| Autor: | W. Rudnicka, Włodzimierz Maśliński, Mariola Kurowska, D. Maślińska |
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| Rok vydání: | 2002 |
| Předmět: |
Fetal Proteins
Gene isoform Hippocampus Gestational Age Nerve Tissue Proteins Biology General Biochemistry Genetics and Molecular Biology Embryonic and Fetal Development Thalamus History and Philosophy of Science Cerebellum Cortex (anatomy) medicine Humans Protein Isoforms RNA Messenger Receptor Cerebral Cortex Interleukin-15 Fetal protein Receptors Interleukin-15 General Neuroscience Brain Gene Expression Regulation Developmental Receptors Interleukin-2 Protein Subunits Interleukin-15 receptor medicine.anatomical_structure Interleukin 15 Cerebral cortex Neuroscience |
| Zdroj: | Annals of the New York Academy of Sciences. 966:441-445 |
| ISSN: | 1749-6632 0077-8923 |
| DOI: | 10.1111/j.1749-6632.2002.tb04245.x |
| Popis: | IL-15, a key cytokine linking innate and acquired immunity, is expressed in many cell types and tissues. Recent data indicate constitutive expression of IL-15 in human neural cell lines and tissues. The aim of the present study was to examine the expression patterns of mRNA encoding IL-15 and IL-15 receptor alpha (IL-15Ralpha) isoforms in select structures of human fetal brain. We report that mRNA for IL-15 and IL-15Ralpha isoforms were expressed in all tested brain structures: cerebral cortex, cerebellum, hippocampus, and thalamus. However, the levels of IL-15 and IL-15Ralpha mRNA were higher in the hippocampus and cerebellum in comparison with cortex and thalamus. Moreover, higher levels of cytosol in comparison with membrane-bound IL-15 isoform were present in all brain structures. The constitutive, but distinct, expression of IL-15 and its receptors in select human fetal brain structures suggests that IL-15 plays a role in their development and physiology. |
| Databáze: | OpenAIRE |
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