Sensitivity booster for mass detection enables unambiguous analysis of peptides, proteins, antibodies, and protein bioconjugates

Autor:	Rohith Singudas, Neelesh C Reddy, Vishal Rai
Rok vydání:	2019
Předmět:	Peptide 010402 general chemistry Tandem mass spectrometry Mass spectrometry 01 natural sciences Peptide Mapping Sensitivity and Specificity Catalysis Tandem Mass Spectrometry Materials Chemistry chemistry.chemical_classification biology 010405 organic chemistry Chemistry Peptide mapping Lysine Metals and Alloys A protein Cytochromes c Proteins General Chemistry 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Matrix-assisted laser desorption/ionization Biochemistry Spectrometry Mass Matrix-Assisted Laser Desorption-Ionization Ceramics and Composites biology.protein Antibody Peptides
Zdroj:	Chemical communications (Cambridge, England). 55(67)
ISSN:	1364-548X
Popis:	A chemical tag enhances peptide detection by multiple orders in mass spectrometry. The substantial improvement in the peptide mapping along with simplified and enhanced fragmentation pattern enables the unambiguous sequencing of a protein and antibody. The chemoselective sensitivity booster provides a tool for remarkably improved analysis of protein bioconjugates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b2159c24f2cf8dbd9beaceb75d02a90 https://pubmed.ncbi.nlm.nih.gov/31367719 Zobrazit plný text záznamu