Comparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)
| Autor: | Natália J. Mendes, Fausto Foresti, Fernando Fernandes Mendonça, Rodrigo Rodrigues Domingues, Vanessa Paes da Cruz, Vito A. Mastrochirico-Filho, Diogo Teruo Hashimoto, Rui Coelho, Agostinho Antunes |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP), Universidade Estadual Paulista (Unesp), I.P.), Universidade do Algarve, Universidade do Porto |
| Rok vydání: | 2020 |
| Předmět: |
0106 biological sciences
Opsin Isurus genetic structures Population Gene Expression Biology Eye 01 natural sciences Transcriptome 03 medical and health sciences Neoplasms Genetics medicine Animals RNA Messenger Eye Proteins Transcriptomics education Gene Vision Ocular Disease Resistance Tumor suppression 030304 developmental biology Genetics & Heredity 0303 health sciences education.field_of_study Messenger RNA Elasmobranch Opsins Photoreception Cancer Molecular Sequence Annotation medicine.disease biology.organism_classification Liver Biotechnology & Applied Microbiology Shortfin mako shark Sharks Gene ontology sense organs 010606 plant biology & botany |
| Zdroj: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0888-7543 |
| Popis: | Made available in DSpace on 2020-12-12T02:21:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-11-01 European Regional Development Fund Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The shortfin mako, Isurus oxyrinchus is an oceanic pelagic shark found worldwide in tropical and subtropical waters. However, the understanding of its biology at molecular level is still incipient. We sequenced the messenger RNA isolated from eye and liver tissues. De novo transcriptome yielded a total of 705,940 transcripts. A total of 3774 genes were differentially expressed (DEGs), with 1612 in the eye and 2162 in the liver. Most DEGs in the eye were related to structural and signaling functions, including nonocular and ocular opsin genes, whereas nine out of ten most overexpressed genes in the liver were related to tumor suppression, wound healing, and human diseases. Furthermore, DEGs findings provide insights on the monochromatic shark vision and a repertory of cancer-related genes, which may be insightful to elucidate shark resistance to cancer. Therefore, our results provide valuable sequence resources for future functional and population studies. Departamento de Ciências do Mar Instituto do Mar Universidade Federal de São Paulo – UNIFESP, Rua Carvalho de Mendonça, 144 Centro de Aquicultura da UNESP Universidade Estadual Paulista – UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n Instituto Português do Mar e da Atmosfera (IPMA I.P.), Av. 5 Outubro Centro de Ciências do Mar (CCMAR) Universidade do Algarve, Campus de Gambelas Laboratório de Biologia e Genética de Peixes Instituto de Biociências de Botucatu Universidade Estadual Paulista – UNESP CIIMAR/CIMAR Centro Interdisciplinar de Investigação Marinha e Ambiental Universidade do Porto, Av. General Norton de Matos, s/n Departmento de Biologia Faculdade de Ciências Universidade do Porto, Rua do Campo Alegre, s/n Centro de Aquicultura da UNESP Universidade Estadual Paulista – UNESP, Via de Acesso Prof. Paulo Donato Castellane, s/n Laboratório de Biologia e Genética de Peixes Instituto de Biociências de Botucatu Universidade Estadual Paulista – UNESP FAPESP: 2014/19740-7 FAPESP: 2017/02420-8 FAPESP: 2018/21319-9 |
| Databáze: | OpenAIRE |
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