EbpR Is Important for Biofilm Formation by Activating Expression of the Endocarditis and Biofilm-Associated Pilus Operon (ebpABC) of Enterococcus faecalis OG1RF▿
| Autor: | Kavindra V. Singh, Barbara E. Murray, Kathryn J. Pflughoeft, Danielle A. Garsin, Agathe Bourgogne, Kristina A. Fox |
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| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Regulation of gene expression
Molecular Biology of Pathogens biology Operon Mutant Biofilm Gene Expression Regulation Bacterial biochemical phenomena metabolism and nutrition biology.organism_classification Microbiology Enterococcus faecalis Pilus Bacterial Adhesion Bacterial genetics Bacterial Proteins Biofilms Fimbriae Bacterial bacteria Molecular Biology Bacteria Gene Deletion Transcription Factors |
| Popis: | We identify ef1090 (renamed ebpR ) and show its importance for the transcriptional regulation of expression of the Enterococcus faecalis pilus operon, ebpABC . An ebpR deletion (Δ ebpR ) mutant was found to have reduced ebpABC expression with loss of pilus production and a defect in primary adherence with, as a consequence, reduced biofilm formation. |
| Databáze: | OpenAIRE |
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