Effects of macrolides on antigen-induced increases in cough reflex sensitivity in guinea pigs
| Autor: | Masaki Fujimura, Miki Abo, Shiho Furusho, Akira Tokuda, Noriyuki Ohkura, Nobuyuki Katayama |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Eosinophilic bronchitis Prostaglandin E2 Cough reflex Guinea Pigs Erythromycin Eosinophilic airway inflammation Substance P Leukotriene B4 Dinoprostone chemistry.chemical_compound Reflex Eosinophilic medicine Animals Pharmacology (medical) Antigens Cough response medicine.diagnostic_test Inhalation business.industry Biochemistry (medical) respiratory system medicine.disease Macrolide antibiotics Anti-Bacterial Agents respiratory tract diseases Chronic cough Bronchoalveolar lavage Cough chemistry Immunology Macrolides Capsaicin medicine.symptom business Bronchoalveolar Lavage Fluid Histamine medicine.drug |
| Zdroj: | Pulmonary Pharmacology & Therapeutics. 23:55-61 |
| ISSN: | 1094-5539 |
| Popis: | 金沢大学医薬保健研究域医学系 Background: Macrolides are antibiotics that have anti-inflammatory activities. Hence, they are used for both acute and chronic inflammatory airway diseases. However, the effects of these agents on allergic airway disorders presenting with an isolated chronic cough, such as non-asthmatic eosinophilic bronchitis and eosinophilic tracheobronchitis with cough hypersensitivity (atopic cough), still remain to be elucidated. Objective: To determine if macrolides are effective in the management of chronic cough caused by eosinophilic airway inflammation. Methods: The cough reflex sensitivity to inhaled capsaicin was measured at 48 h after challenge with an aerosolized antigen in actively sensitized guinea pigs. The 14-, 15- or 16-membered macrolides (erythromycin, azythromycin, or josamycin, respectively) were given intraperitoneally every 12 h after the antigen challenge. Bronchoalveolar lavage and the resection of the tracheal tissue were performed immediately after the measurement of the cough response to capsaicin. Results: The antigen-induced increase in the number of coughs elicited by capsaicin inhalation was significantly reduced by treatments with erythromycin and azythromycin, but not with josamycin. Erythromycin dose-dependently inhibited the increases in the substance P, prostaglandin E2 and leukotriene B4 levels, but not the histamine levels, in the bronchoalveolar lavage fluid. However, erythromycin did not influence the antigen-induced decrease in the neutral endopeptidase (NEP) activity in the tracheal tissue. Conclusions: Both 14- and 15-membered, but not 16-membered, macrolides could reduce the antigen-induced cough reflex hypersensitivity by inhibiting the antigen-induced release of the afferent sensory nerve sensitizers. These macrolides may be therapeutically useful for the treatment of isolated chronic cough based on cough reflex hypersensitivity in allergic airway diseases such as non-asthmatic eosinophilic bronchitis and atopic cough. © 2009 Elsevier Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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