Do changes in microglial status underlie neurogenesis impairments and depressive-like behaviours induced by psychological stress? A systematic review in animal models
| Autor: | Carmen Pedraza, Margarita Pérez-Martín, Patricia Chaves-Peña, Luis J. Santín, Andrea Nieto-Quero |
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| Přispěvatelé: | [Nieto-Quero,A, Chaves-Peña,P, Santín,LJ, Pedraza,C] Departamento de Psicobiología y Metodología en las CC, Universidad de Málaga, Málaga, Spain. [Chaves-Peña,P, Pérez-Martín,M] Departamento de Biología Celular, Genética y Fisiología, Universidad de Málaga, Málaga, Spain. [Nieto-Quero,A, Pérez-Martín,M, Pedraza,C] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain., This study was supported by FEDER/Ministerio de Ciencia, Innovación y Universidades – Agencia Estatal de Investigación (PSI 2017-83408-P) to C.P. and Ministerio de Universidades (FPU16/05308 to AN-Q). PC-P has been funded by the research project PSI 2017-83408-P as technician (ci-19-082). |
| Rok vydání: | 2021 |
| Předmět: |
Neurogénesis
Physiology Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis [Medical Subject Headings] Hippocampus Hippocampal formation Biochemistry 0302 clinical medicine Endocrinology Neuroinflammation Depresión Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress Psychological [Medical Subject Headings] Organisms::Eukaryota::Animals [Medical Subject Headings] Medicine Depression (differential diagnoses) Neurobiología del desarrollo Depression QP351-495 Neurogenesis Animal models Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Health [Medical Subject Headings] Microglía Microglia RC321-571 Neurophysiology and neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry Anatomy::Nervous System::Neuroglia::Microglia [Medical Subject Headings] Psychosocial stress 03 medical and health sciences Cellular and Molecular Neuroscience Review article Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus [Medical Subject Headings] RC346-429 Molecular Biology Endocrine and Autonomic Systems business.industry Revisión sistemática Modelos animales Mental health Psychiatry and Psychology::Mental Disorders::Mood Disorders [Medical Subject Headings] 030227 psychiatry Mood Environmental Risk Factor Systematic review Neurology. Diseases of the nervous system business Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression [Medical Subject Headings] Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurobiology of Stress Neurobiology of Stress, Vol 15, Iss, Pp 100356-(2021) RIUMA. Repositorio Institucional de la Universidad de Málaga instname |
| ISSN: | 2352-2895 |
| Popis: | Stress may have a negative effect on mental health and is the primary environmental risk factor in the aetiology of depression. Nevertheless, the neurobiological mechanisms underlying this mood disorder remain poorly characterized. The hippocampus is a target structure of the adverse effects of stress, and hippocampal neuro- genesis plays a crucial role. However, we do not know the mechanisms by which stress impacts neurogenesis. Recent studies indicate that changes in neuroinflammation, primarily via microglial cells, may play an essential role in this process. However, the relationship between stress, microglial changes, and alterations in neurogenesis and their involvement in the development of depression is poorly characterized. For this reason, this systematic review aims to synthesise and evaluate current studies that have investigated the relationship between these variables. Taken together, the revised data, although not entirely conclusive, seem to suggest that microglial changes induced by psychological stress regulate neurogenesis and in turn may be responsible for the devel- opment of depressive-like behaviours, but other factors that influence these stressful experiences should not be dismissed. We would like to thank the University of Malaga/CBUA for the contribution to the payment of the open access charge. This study was supported by FEDER/Ministerio de Ciencia, Innovacion ´ y Universidades – Agencia Estatal de Investigacion ´ (PSI 2017-83408-P) to C.P. and Ministerio de Universidades (FPU16/05308 to AN-Q). PC-P has been funded by the research project PSI 2017-83408- P as technician (CI-19-082). |
| Databáze: | OpenAIRE |
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