Chronic eosinophilic leukemia presenting with autoimmune hemolytic anemia and erythrophagocytosis by eosinophils
| Autor: | Kuk Js, McFarlane A, A. Benger, P. Soamboonsrup, W. Patterson, Michael Trus, Maceachern Ja, Yang L |
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| Rok vydání: | 2006 |
| Předmět: |
Hemolytic anemia
Male Pathology medicine.medical_specialty Erythrocytes Hypereosinophilia Leukocyte Count Phagocytosis Bone Marrow hemic and lymphatic diseases Hypereosinophilic Syndrome Medicine Humans Aged Glycoproteins Myelopoiesis Chronic eosinophilic leukemia business.industry Lymphoma Non-Hodgkin Neoplasms Second Primary Hematology respiratory system Eosinophil medicine.disease Erythrophagocytosis Eosinophils Leukemia medicine.anatomical_structure Immunology Bone marrow Anemia Hemolytic Autoimmune medicine.symptom Autoimmune hemolytic anemia business Lysophospholipase |
| Zdroj: | American journal of hematology. 81(6) |
| ISSN: | 0361-8609 |
| Popis: | Eosinophils function primarily as secretory cells and phagocytosis by eosinophils is rarely seen. We describe a case of chronic eosinophilic leukemia (CEL) in a 72-year-old male with a history of previously treated non-Hodgkin's lymphoma (NHL) presenting with erythrophagocytosis by eosinophils and an associated autoimmune hemolytic anemia (AIHA). This patient did not show evidence of relapsed NHL. The patient's blood showed a markedly elevated eosinophil count of 16 x 10(9)/L [normal 0-0.45 x 10(9)/L] on a background of myelodysplasia and features of AIHA. Prominent erythrophagocytosis by eosinophils was visualized in the blood and in the bone marrow. Numerous Charcot-Leyden crystals were also seen in the bone marrow amid increased numbers of eosinophils and the presence of dysplastic granulopoiesis. AIHA is rarely described in the setting of CEL. More significantly, this represents the first case report to describe erythrophagocytosis by eosinophils. |
| Databáze: | OpenAIRE |
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