Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer’s Disease in a Mouse Model
| Autor: | Vadim Y. Arshavsky, Zachary A. Steelman, Adam Wax, Ge Song, Stella Finkelstein, L. Martin, Sina Farsiu, Ziyun Yang, Kengyeh K. Chu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pathology
medicine.medical_specialty genetic structures Biopsy Nerve fiber layer Outer plexiform layer lcsh:Medicine Fluorescent Antibody Technique Mice Transgenic Light scattering Article Retina 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Optical coherence tomography Alzheimer Disease medicine Image Processing Computer-Assisted Animals lcsh:Science Multidisciplinary medicine.diagnostic_test Scattering Chemistry lcsh:R Imaging and sensing Coherent imaging Retinal Signal Processing Computer-Assisted Disease Models Animal medicine.anatomical_structure 030221 ophthalmology & optometry lcsh:Q Pigmented Epithelium sense organs Biomedical engineering 030217 neurology & neurosurgery Biomarkers Tomography Optical Coherence |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| Popis: | We acquired depth-resolved light scattering measurements from the retinas of triple transgenic Alzheimer’s Disease (3xTg-AD) mice and wild type (WT) age-matched controls using co-registered angle-resolved low-coherence interferometry (a/LCI) and optical coherence tomography (OCT). Angle-resolved light scattering measurements were acquired from the nerve fiber layer, outer plexiform layer, and retinal pigmented epithelium using image guidance and segmented thicknesses provided by co-registered OCT B-scans. Analysis of the OCT images showed a statistically significant thinning of the nerve fiber layer in AD mouse retinas compared to WT controls. The a/LCI scattering measurements provided complementary information that distinguishes AD mice by quantitatively characterizing tissue heterogeneity. The AD mouse retinas demonstrated higher mean and variance in nerve fiber layer light scattering intensity compared to WT controls. Further, the difference in tissue heterogeneity was observed through short-range spatial correlations that show greater slopes at all layers of interest for AD mouse retinas compared to WT controls. A greater slope indicates a faster loss of spatial correlation, suggesting a loss of tissue self-similarity characteristic of heterogeneity consistent with AD pathology. Use of this combined modality introduces unique tissue texture characterization to complement development of future AD biomarker analysis. |
| Databáze: | OpenAIRE |
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