Evaluation of serum alpha fetoprotein-L3 as an accuracy novel biomarker for the early diagnosis of hepatocellular carcinoma in Egyptian patients
| Autor: | Hassnaa M. Ibrahim, Magdy Zaki El-Ghannam, Ahmed M.A. El-Sokkary, Om Ali Y. El-Khawaga |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
HCC Hepatocellular carcinoma Cirrhosis AFP α- fetoprotein Alpha (ethology) Gastroenterology HCV Hepatitis C virus CAH chronic active hepatitis Internal medicine medicine AFP-L3 HCC Stage (cooking) neoplasms Hepatitis business.industry AFP-L3 α- fetoprotein L3 Albumin medicine.disease digestive system diseases Hepatocellular carcinoma Biomarker (medicine) Original Article General Agricultural and Biological Sciences business Biomarkers |
| Zdroj: | Saudi Journal of Biological Sciences |
| ISSN: | 1319-562X |
| DOI: | 10.1016/j.sjbs.2021.06.020 |
| Popis: | Background Most Hepatocellular Carcinomas (HCCs) are diagnosed at an advanced stage. However, HCC early diagnosis is complicated by the coexistence of inflammation and cirrhosis. The unsatisfactory sensitivity and specificity of Alpha-fetoprotien (AFP) for screening of early-stage HCC paved the way for new novel biomarkers to complement AFP such as AFP-L3. The aim of this study was the Evaluation of alpha fetoprotein-L3 (AFP-L3) as earlier marker in diagnosis of hepatocellular carcinoma in Egyptian patients. This study was conducted on 80 patients categorized into 2 groups; group 2 (40 patients with chronic active hepatitis) and group 3 (40 patients with HCC). HCC diagnosis was done by clinical, triphasic CT and positive US for focal lesion, in addition to 20 healthy individuals as controls (group 1). Results The median range of AFP and AFP-L3 were highly statistically significant difference between HCC group and other groups [p |
| Databáze: | OpenAIRE |
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