Linezolid for the treatment of infections caused by Gram-positive pathogens in China
| Autor: | Dong-fang Lin, Margaret Marian Ijzerman, Li-ye Zheng, Xin Zhou, Fu Wang, Hua-hao Shen, Yingyuan Zhang, Jing-zhi Miao, Rodney V. Croos-Dabrera, Rui-yuan Sheng, Ju-fang Wu, Jing-chuan Zheng, Wei Sheng |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty China Meticillin Adolescent medicine.drug_class Antibiotics medicine.disease_cause chemistry.chemical_compound Double-Blind Method Vancomycin Internal medicine Acetamides medicine Pneumonia Bacterial Humans Pharmacology (medical) Adverse effect Gram-Positive Bacterial Infections Oxazolidinones Antibacterial agent Aged Cross Infection business.industry Soft Tissue Infections Linezolid General Medicine Skin Diseases Bacterial biochemical phenomena metabolism and nutrition Middle Aged medicine.disease Surgery Anti-Bacterial Agents Gram-Positive Cocci Pneumonia Infectious Diseases Treatment Outcome chemistry Staphylococcus aureus Female business medicine.drug |
| Zdroj: | International journal of antimicrobial agents. 32(3) |
| ISSN: | 0924-8579 |
| Popis: | In this randomised, double-blind, comparator-controlled, multicentre study conducted in China, 142 hospitalised patients aged 18-75 years with pneumonia (n=80) or complicated skin and soft-tissue infection (cSSTI) (n=62) due to suspected or known Gram-positive pathogens were randomised (1:1) to receive either linezolid 600mg (n=71) or vancomycin 1g in patients agedor =60 years or 0.75g in patients aged60 years (n=71) intravenously every 12h. The duration of treatment was 10-21 days for patients with pneumonia and 7-21 days for patients with cSSTI. Clinical outcomes were assessed at end-of-treatment (EOT) visit and follow-up (FU) visit 7-28 days post therapy. Staphylococcus aureus was the most common pathogen at baseline and most of these isolates were resistant to meticillin. All isolates were susceptible to linezolid and vancomycin. For the evaluable patients, the effective treatment rate for linezolid was higher than that for vancomycin at EOT (86.9% (53/61) vs. 61.7% (37/60)) and at FU (83.1% (49/59) vs. 64.9% (37/57)). Pathogen eradication rates for the microbiologically evaluable patients at FU were 79.2% (42/53) for linezolid and 61.5% (32/52) for vancomycin. The incidence of drug-related adverse events (AEs) was 25.4% (18/71) for linezolid and 16.9% (12/71) for vancomycin. Four (5.6%) linezolid-treated and eight (11.3%) vancomycin-treated patients discontinued the study drug because of an AE. Linezolid was well tolerated and effective for the treatment of infections caused by Gram-positive pathogens, including meticillin-resistant S. aureus. |
| Databáze: | OpenAIRE |
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