Epigenetic dysregulation of secreted Frizzled-related proteins in multiple myeloma
| Autor: | James G. Herman, Edgar Jost, R. Osieka, Stefan Wilop, Oliver Galm, Deniz Gezer, Hiromu Suzuki |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research Frizzled Biology Epigenesis Genetic Leukemia Plasma Cell Cell Line Tumor Proto-Oncogene Proteins medicine Humans Sulfites Gene silencing Epigenetics Eye Proteins Promoter Regions Genetic Multiple myeloma Adaptor Proteins Signal Transducing Aged Aged 80 and over Reverse Transcriptase Polymerase Chain Reaction Infant Newborn Wnt signaling pathway Membrane Proteins DNA Neoplasm DNA Methylation Middle Aged medicine.disease Survival Analysis Molecular biology Neoplasm Proteins Wnt Proteins Oncology DNA methylation Cancer research Intercellular Signaling Peptides and Proteins CpG Islands Female SFRP4 Multiple Myeloma Monoclonal gammopathy of undetermined significance |
| Zdroj: | Cancer Letters. 281:24-31 |
| ISSN: | 0304-3835 |
| DOI: | 10.1016/j.canlet.2009.02.002 |
| Popis: | We analysed the clinical impact of epigenetic dysregulation of the Wnt pathway in malignant plasma cell disorders. In multiple myeloma (MM) cell lines, aberrant promoter hypermethylation of the secreted Frizzled-related protein (SFRP) genes was a common event, and hypermethylation of SFRP1,-2 and -5 was associated with transcriptional silencing. Among 76 primary patient samples, the frequency of aberrant methylation was 35.5% for SFRP1, 52.6% for SFRP2, 1.3% for SFRP4 and 6.9% for SFRP5. Hypermethylation of SFRP1 and -2 genes was detected in monoclonal gammopathy of undetermined significance and all MM stages including plasma cell leukaemia (PCL), while SFRP5 methylation was restricted to advanced MM stages and PCL. Our data indicate that epigenetic silencing of Wnt antagonists is an early event in MM pathogenesis and that SFRP5 hypermethylation may play a role in disease progression. |
| Databáze: | OpenAIRE |
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