| Autor: |
Kevin M. Turner, Aaron M. Delman, Eileen C. Donovan, John Brunner, Shaun A. Wahab, Yufei Dai, Kyuran A. Choe, Milton T. Smith, Sameer H. Patel, Syed A. Ahmad, Gregory C. Wilson |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
HPB : the official journal of the International Hepato Pancreato Biliary Association. 24(11) |
| ISSN: |
1477-2574 |
| Popis: |
Total pancreatectomy and islet cell autotransplantation (TPIAT) offers an effective, lasting solution for the management of chronic pancreatitis up to 5-years post-operatively. Our aim was to assess durability of TPIAT at 10-years.Patients undergoing TPIAT for chronic pancreatitis eligible for 10-year follow-up were included. Primary outcomes, including endocrine function and narcotic requirements, were reported at 5-, 7.5-, and 10-years post-operatively.Of the 231 patients who underwent TPIAT, 142 met inclusion criteria. All patients underwent successful TPIAT with an average of 5680.3 islet equivalents per body weight. While insulin independence tended to decrease over time (25.7% vs. 16.0% vs. 10.9%, p = 0.11) with an increase in HbAThis study represents one of the largest series reporting on long-term outcomes after TPIAT, demonstrating excellent long-term pain control and durable improvements in quality of life. Islet cell function declines over time however stable glycemic control is maintained. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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