Increased gastrointestinal permeability in patients with Plasmodium falciparum malaria
| Autor: | Polrat Wilairatana, Sornchi Looareesuwan, Winkler Weinberg, Jon B. Meddings, May Ho, Suparb Vannaphan |
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| Rok vydání: | 1997 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Sucrose Cell Membrane Permeability Adolescent media_common.quotation_subject Parasitemia Urine Gastroenterology Lactulose Internal medicine parasitic diseases Medicine Humans Mannitol Intestinal Mucosa Malaria Falciparum media_common biology business.industry Convalescence Plasmodium falciparum medicine.disease biology.organism_classification Infectious Diseases Intestinal Absorption Gastric Mucosa Immunology Female business Complication Malaria medicine.drug |
| Zdroj: | Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 24(3) |
| ISSN: | 1058-4838 |
| Popis: | Sequential gastrointestinal permeability in patients with Plasmodium falciparum malaria was determined by measuring the permeation of sucrose, lactulose, and mannitol to assess both gastric and small intestine permeability. Sucrose absorption (gastroduodenal permeability) was increased in patients with severe malaria (defined as either >5% parasitemia or a serum bilirubin level of >50 μmol/L) and became normal by day 2 following treatment. A similar proportion of patients with uncomplicated malaria had increased gastroduodenal permeability initially, which resolved by day 7 of treatment. During acute malarial illness, the lactulose: mannitol (L:M) ratio in urine was increased and was found to be higher in patients with severe malaria than in those with uncomplicated malaria and in controls, but this ratio reverted to normal during convalescence. At the time of admission, the L:M ratios in patients with uncomplicated malaria were increased but became normal by day 2 after treatment. Conversely, the duration of increased L:M ratios in patients with severe malaria was longer. By day 7, the L:M ratios in patients with severe malaria were higher than those in patients with uncomplicated malaria and in controls. We conclude that gastrointestinal permeability is increased during severe and uncomplicated falciparum malaria but reverts to normal during convalescence. |
| Databáze: | OpenAIRE |
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