Prevalence of hepatitis B and C markers in a population of an urban university in Rio de Janeiro, Brazil: a cross-sectional study
| Autor: | Luís Cristóvão Porto, Daniele Blasquez Olmedo, Fernanda R.S. Barquette, Magda Cristina Bernardino Castilho, Suely G.C. Silva, Orlando C. Ferreira, Patrícia Marraccini Precioso, Félix P.D. Pinto |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
HBsAg Time Factors Epidemiology Hepacivirus Specialties of internal medicine medicine.disease_cause Seroepidemiologic Studies Prevalence Child education.field_of_study biology virus diseases General Medicine Hepatitis C Middle Aged Viral Load Hepatitis B Phenotype RC581-951 Child Preschool Female Viral load Brazil Adult Hepatitis B virus medicine.medical_specialty Adolescent Genotype Universities Population Young Adult Predictive Value of Tests Internal medicine medicine Humans Hepatitis B Antibodies education Hepatitis Hepatology Anti-HCV business.industry Urban Health Hepatitis C Antibodies medicine.disease biology.organism_classification Virology Anti-HBs digestive system diseases Cross-Sectional Studies Socioeconomic Factors Risk factors DNA Viral business Biomarkers |
| Zdroj: | Annals of Hepatology, Vol 14, Iss 6, Pp 815-825 (2015) |
| ISSN: | 1665-2681 |
| Popis: | Background and rationale. Epidemics of hepatitis B and C are a public health burden, and their prevalence in Brazil varies among regions. We determined the prevalence of hepatitis markers in an urban university population in order to support the development of a comprehensive program for HBV immunization and HBV/HCV diagnosis. Students, employees, and visitors (n = 2,936, 31 years IQR 24.5-50, female = 69.0% and 81.1% with at least 12 years of education) were enrolled from May to November 2013. Antibodies against hepatitis B surface antigen (anti-HBs), against hepatitis B core antigen (anti-HBc), and hepatitis B surface antigen (HBsAg) were detected with enzyme immunoassays and anti-hepatitis C virus (anti-HCV) antibodies with a chemiluminescence immunoassay. The results were confirmed with polymerase chain reaction for HCV and nucleic acid amplification test for hepatitis B virus (HBV). Results. The overall prevalence of markers among the participants was 0.136% (95% confidence interval [CI]: 0.003-0.270) for HBsAg, 6.44% (95% CI: 5.55-7.33%) for anti-HBc, 50.8% (95% CI: 48.9-52.7%) for anti-HBs > 10 mIU/mL, and 0.44% (95% CI: 0.20-0.68) for anti-HCV. Almost 30.4% had anti-HBs titers > 100 mIU/mL. Participants with a detectable HCV viral load (n = 9) were infected with genotype 1a. Conclusions. In an urban university population, in which 80% of participants had > 11 years of education, prevalence increased with age, and self-declared ethnicity for anti-HBc and with age, marital status and professional activity for anti-HCV antibodies. A periodical offer of HCV rapid testing should be implemented, and HBsAg rapid testing should be offered to individuals above 20 years of age. |
| Databáze: | OpenAIRE |
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