Salivary Interleukin-6 and C-Reactive Protein/Mean Platelet Volume Ratio in the Diagnosis of Late-Onset Neonatal Pneumonia

Autor:	Ahmed R. Rezk, Sonya El-Sharkawy, Ahmed Omran, Mohamed Osama Abdalla, Abdelmoneim Khashana, Yasmin Ali
Rok vydání:	2021
Předmět:	Male Neonatal pneumonia medicine.medical_specialty Article Subject Immunology Late onset Gastroenterology Predictive Value of Tests Internal medicine Case fatality rate Humans Immunology and Allergy Medicine Prospective Studies Respiratory system Mean platelet volume Saliva Interleukin 6 biology medicine.diagnostic_test Interleukin-6 business.industry C-reactive protein Infant Newborn Complete blood count Pneumonia General Medicine RC581-607 C-Reactive Protein Case-Control Studies biology.protein Feasibility Studies Female Immunologic diseases. Allergy business Mean Platelet Volume Biomarkers Research Article
Zdroj:	Journal of Immunology Research, Vol 2021 (2021) Journal of Immunology Research
ISSN:	2314-7156 2314-8861
Popis:	Neonatal pneumonia is a serious respiratory infectious disease with a high rate of case fatality in developing countries. Salivary cytokines could serve as interesting noninvasive markers in the diagnosis of neonatal pneumonia. The aim was to assess the diagnostic role of salivary and serum interleukin-6 (IL-6), C-reactive protein/mean platelet volume (CRP/MPV) ratio, and the combination of these markers in the diagnosis of late-onset neonatal pneumonia in full-term neonates. Seventy full-term neonates, 35 with late-onset neonatal pneumonia and 35 controls, were enrolled in this prospective case-control study. Complete blood count (CBC), salivary and serum IL-6, and CRP concentrations were measured for all the study subjects. The sensitivity, specificity, positive predictive value, and negative predictive value of salivary IL-6, serum IL-6, and CRP/MPV ratio for the diagnosis of late-onset neonatal pneumonia were determined. At the cutoff point of >34 pg/ml, salivary IL-6 showed 82.86% sensitivity and 91.43% specificity. CRP/MPV ratio showed a sensitivity of 97.14% and specificity of 85.71% at a cutoff value > 0.88 . The combination of salivary IL-6 and CRP/MPV ratio improved the sensitivity and specificity to 100%. The current study shows for the first time that both salivary IL-6 and CRP/MPV ratio are suitable markers for the diagnosis of late-onset neonatal pneumonia in full-term neonates.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b0c26ee9c808ca1c60d28cba564fda9 https://doi.org/10.1155/2021/8495889 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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