The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies
| Autor: | Piotr Wlaź, Aleksandra Pochodyła, Aleksandra Szopa, Slawomir Mandziuk, Aleksandra Wlaź, Maria Radziwoń-Zaleska, Mariola Herbet, Andrzej Wróbel, Karolina Bogatko, Anna Kudela, Anna Serefko, Katarzyna Świąder, Ewa Poleszak, Marta Ostrowska, Bernadeta Szewczyk, Sylwia Wośko, Jarosław Dudka, Piotr Skałecki |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine inorganic chemicals istradefylline antidepressant activity Receptor Adenosine A2A medicine.drug_class DPCPX chemistry.chemical_element Adenosine A1 Receptor Antagonists Pharmacology magnesium Catalysis Article Inorganic Chemistry lcsh:Chemistry Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Physical and Theoretical Chemistry Receptor Molecular Biology lcsh:QH301-705.5 Spectroscopy Behavior Animal Receptor Adenosine A1 Magnesium Zinc ion Organic Chemistry zinc General Medicine Istradefylline Receptor antagonist Adenosine receptor Adenosine A2 Receptor Antagonists Computer Science Applications 030104 developmental biology chemistry lcsh:Biology (General) lcsh:QD1-999 Xanthines Antidepressant 030217 neurology & neurosurgery MSRA |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 1840, p 1840 (2021) Volume 22 Issue 4 |
| ISSN: | 1422-0067 |
| Popis: | The purpose of the study was to investigate whether the co-administration of Mg2+ and Zn2+ with selective A1 and A2A receptor antagonists might be an interesting antidepressant strategy. Forced swim, tail suspension, and spontaneous locomotor motility tests in mice were performed. Further, biochemical and molecular studies were conducted. The obtained results indicate the interaction of DPCPX and istradefylline with Mg2+ and Zn2+ manifested in an antidepressant-like effect. The reduction of the BDNF serum level after co-administration of DPCPX and istradefylline with Mg2+ and Zn2+ was noted. Additionally, Mg2+ or Zn2+, both alone and in combination with DPCPX or istradefylline, causes changes in Adora1 expression, DPCPX or istradefylline co-administered with Zn2+ increases Slc6a15 expression as compared to a single-drug treatment, co-administration of tested agents does not have a more favourable effect on Comt expression. Moreover, the changes obtained in Ogg1, MsrA, Nrf2 expression show that DPCPX-Mg2+, DPCPX-Zn2+, istradefylline-Mg2+ and istradefylline-Zn2+ co-treatment may have greater antioxidant capacity benefits than administration of DPCPX and istradefylline alone. It seems plausible that a combination of selective A1 as well as an A2A receptor antagonist and magnesium or zinc may be a new antidepressant therapeutic strategy. |
| Databáze: | OpenAIRE |
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