Vaso-occlusive Retinopathy Associated with Anti-phospholipid Antibodies (lupus anticoagulant retinopathy)
| Autor: | Robert C. Kleiner, Douglas A. Jabs, Henry J. Kaplan, Lawrence V. Najarian, Sam Schatten, Arnall Patz |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Prolonged Partial Thromboplastin Time genetic structures Cardiolipins Visual Acuity Enzyme-Linked Immunosorbent Assay Light Coagulation Neovascularization Retinal Diseases immune system diseases Ophthalmology medicine Humans Fluorescein Angiography skin and connective tissue diseases Autoimmune disease Retinal Vascular Occlusion Lupus anticoagulant Lupus erythematosus Neovascularization Pathologic business.industry Retinal Vessels Middle Aged medicine.disease Blood Coagulation Factors eye diseases Lupus Coagulation Inhibitor Vitreous hemorrhage Immunology Prednisone medicine.symptom business Retinopathy |
| Zdroj: | Ophthalmology. 96:896-904 |
| ISSN: | 0161-6420 |
| Popis: | The authors observed three cases (6 eyes) of vaso-occlusive retinopathy associated with the lupus anticoagulant and the related antiphospholipid antibody anticardiolipin. The disease occurred in patients who had no definable autoimmune disease such as systemic lupus erythematosus (SLE) and was characterized by severe bilateral retinal vascular occlusion. There was profound visual loss from intraretinal ischemia as well as vitreous hemorrhage from preretinal neovascularization. Results of laboratory testing showed a prolonged partial thromboplastin time (PTT) in two patients, and the presence of the lupus anticoagulant in all. Treatment with panretinal photocoagulation appeared to stabilize the neovascularization. The role of systemic anticoagulation and immunosuppressive therapy is uncertain. Ophthalmology 96:896-904,1989 |
| Databáze: | OpenAIRE |
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