Dynamic Contrast-Enhanced Magnetic Resonance Imaging as a Diagnostic Tool in the Assessment of Tumour Angiogenesis in Urinary Bladder Cancer
| Autor: | Rasha T. Abouelkheir, Manal Ezzat Badawy, Mohamed Abd El-Hamid, Omar Ahmad Hassanien, Mohamed Ibrahim Abou El-Ghar, Samir El Gamal |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Tumor angiogenesis Pathology medicine.medical_specialty Urinary Bladder Contrast Media Sensitivity and Specificity 030218 nuclear medicine & medical imaging Young Adult 03 medical and health sciences 0302 clinical medicine Humans Medicine Radiology Nuclear Medicine and imaging Aged Aged 80 and over Neovascularization Pathologic medicine.diagnostic_test Urinary Bladder Cancer business.industry Magnetic resonance imaging General Medicine Middle Aged Image Enhancement Magnetic Resonance Imaging Dynamic contrast Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Female business |
| Zdroj: | Canadian Association of Radiologists Journal. 70:254-263 |
| ISSN: | 1488-2361 0846-5371 |
| DOI: | 10.1016/j.carj.2018.11.004 |
| Popis: | Purpose The aim of study is to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and correlation with tumour angiogenesis in evaluation of urinary bladder cancer. Material and Methods The study included 81 patients with recent presumed diagnosis of bladder tumour or who came for follow up after management of histopathologically proven bladder cancer. All had DCE-MRI with time–signal intensity curve. The radiologic results then correlated with the histopathologic results using both haematoxylin and eosin stain and immuno-histochemical staining for localization and evaluation of CD34 immunoreactivity as a detector for the microvessel density (MVD) and tumour angiogenesis. Results Seventy-one cases were pathologically proven to be malignant: 41 cases (58%) showed type III time–signal intensity curve (descending); 22 cases (31%) showed type II (plateau); and 8 cases (11%) showed type I (ascending) curve. The sensitivity of DCE-MRI in stage T1 bladder tumour was 80%; in stage T2, it was (90.9%); and in stage T3, it was (96.9%). Overall accuracy of DCE-MRI in tumour staging was 89.5% and P = .001 (significant). Values more than the cutoff value = 76.13 MVD are cystitis with sensitivity (90%), specificity (91%), and P value is .001, which is statistically highly significant. Conclusion There is a strong positive association between DCE-MRI (staging and washout slope of the time–signal intensity curve) with histopathologic grade, tumour stage, and MVD in bladder cancer. So, DCE-MRI can be used as reliable technique in preoperative predictions of tumour behavior and affect the planning of antiangiogenetic therapy. |
| Databáze: | OpenAIRE |
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