CDK9 keeps RNA polymerase II on track
| Autor: | Sylvain Egloff |
|---|---|
| Přispěvatelé: | Centre de Biologie Intégrative (CBI), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire de biologie moléculaire eucaryote (LBME), Centre National de la Recherche Scientifique (CNRS)-Centre de Biologie Intégrative (CBI), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Cyclin T1
Transcription Genetic [SDV]Life Sciences [q-bio] RNA polymerase II Review 7SK RNA 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Transcription (biology) Gene expression Animals Humans Transcriptional checkpoint Phosphorylation P-TEFb Molecular Biology Gene 030304 developmental biology Pharmacology 0303 health sciences biology HIV Cell Biology Cyclin-Dependent Kinase 9 Cyclin-Dependent Kinases Cell biology biology.protein Promoter-proximal pausing Molecular Medicine Cyclin-dependent kinase 9 RNA Polymerase II 030217 neurology & neurosurgery RNA polymerase II CTD |
| Zdroj: | Cellular and Molecular Life Sciences Cellular and Molecular Life Sciences, Springer Verlag, 2021, 78 (14), pp.5543-5567. ⟨10.1007/s00018-021-03878-8⟩ |
| ISSN: | 1420-682X 1420-9071 |
| DOI: | 10.1007/s00018-021-03878-8⟩ |
| Popis: | Cyclin-dependent kinase 9 (CDK9), the kinase component of positive transcription elongation factor b (P-TEFb), is essential for transcription of most protein-coding genes by RNA polymerase II (RNAPII). By releasing promoter-proximally paused RNAPII into gene bodies, CDK9 controls the entry of RNAPII into productive elongation and is, therefore, critical for efficient synthesis of full-length messenger (m)RNAs. In recent years, new players involved in P-TEFb-dependent processes have been identified and an important function of CDK9 in coordinating elongation with transcription initiation and termination has been unveiled. As the regulatory functions of CDK9 in gene expression continue to expand, a number of human pathologies, including cancers, have been associated with aberrant CDK9 activity, underscoring the need to properly regulate CDK9. Here, I provide an overview of CDK9 function and regulation, with an emphasis on CDK9 dysregulation in human diseases. |
| Databáze: | OpenAIRE |
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