Immune modulation by rebamipide in a mouse model of Sjogren’s syndrome via T and B cell regulation
| Autor: | Park Sung-Hwan, Yang SeungCheon, Choi JeongWon, Hwang Sun-Hee, Cho Mi-La, Jung Kyung-Ah, Park Jin-Sil |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Regulatory B cells Immunology Nod Quinolones Salivary Glands Immunomodulation Mice 03 medical and health sciences 0302 clinical medicine Immune system Animals Immunology and Allergy Medicine IL-2 receptor B cell B-Lymphocytes Regulatory Alanine business.industry FOXP3 Disease Models Animal Sjogren's Syndrome 030104 developmental biology medicine.anatomical_structure Oxygenases Cancer research Cytokines Th17 Cells Rebamipide Tumor necrosis factor alpha business 030215 immunology medicine.drug |
| Zdroj: | Immunology Letters. 214:1-7 |
| ISSN: | 0165-2478 |
| DOI: | 10.1016/j.imlet.2019.07.005 |
| Popis: | Rebamipide is a gastroprotective drug used widely in the treatment of gastritis and gastric ulcers. It has also been shown to improve dry eye and dry mouth, two major symptoms of Sjogren’s syndrome (SS). However, little is known about the effects of rebamipide on T and B cell regulation in SS. In this study, we used a NOD/ShiLtJ mouse model of SS to examine the ability of rebamipide to ameliorate disease development by modulating T and B cells. Our results show that the oral administration of rebamipide suppressed SS progression and the level of inflammatory cytokines, including interleukin (IL)-6, tumor necrosis factor-α, and IL-17, in the salivary glands and spleen of NOD/ShiLtJ mice. Rebamipide treatment also increased the number of ex vivo CD19+CD25+Foxp3+ regulatory B cells and CD19+CD5+CD1d + IL-10+ cells in NOD/ShiLtJ mice. In vitro, rebamipide suppressed IL-6 and IL-17 production by Th17 cells in splenic CD4+ cells from the mice. Thus, rebamipide may be effective in controlling the immune imbalance between pathogenic immune cells and regulatory cells, resulting in fundamental improvement in patients with SS. |
| Databáze: | OpenAIRE |
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