In vivo effects of Viscum album and probiotics against carbon tetrachloride-induced liver injury
| Autor: | Betül Can, Semih Öz, Dilek Burukoglu Donmez, Fahrettin Akyüz, Meltem Erdaş, Mete Özkoç |
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| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Viscum album Physiology Bilirubin CCL4 Pharmacology digestive system 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Oral administration parasitic diseases medicine Animals Rats Wistar Carbon Tetrachloride Liver injury biology business.industry Probiotics Therapeutic effect Albumin Cell Biology medicine.disease biology.organism_classification digestive system diseases Rats Disease Models Animal 030104 developmental biology chemistry Chemical and Drug Induced Liver Injury Chronic 030220 oncology & carcinogenesis Carbon tetrachloride business |
| Zdroj: | Journal of Bioenergetics and Biomembranes. 53:139-148 |
| ISSN: | 1573-6881 0145-479X |
| DOI: | 10.1007/s10863-021-09883-7 |
| Popis: | This study tested the possible protective and therapeutic effects of Viscum album extract and probiotics against carbon tetrachloride (CCl4)-induced acute/chronic liver injury. Male Wistar rats were assigned to seven groups: Control, acute CCl4, acute V. album + CCl4, acute V. album + Probiotics + CCl4, chronic CCl4, chronic CCl4 + V. album, and chronic CCl4 + V. album + Probiotics. Acute and chronic liver injuries were induced by 2 mg/kg CCl4 (i.p.) and 1 mg/kg CCl4 (i.p.), respectively. The extract and probiotics were administered daily to related groups. Serum enzyme activities, lipid profile, total protein, albumin, bilirubin, heme oxgenase-1 and 8-hydroxydeoxyguanosine levels were measured. Liver tissue sections stained with Hematoxylin-Eosin. Acute or chronic CCl4-exposure caused to significant changes in concentrations/activities of the measured parameters. The oral administration of extract and probiotics showed protective and therapeutic effects against CCl4-induced liver-injury. The supplementation of intestinal flora by the use of probiotics may enhance the efficacy of orally given therapeutic extracts. |
| Databáze: | OpenAIRE |
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