Expression of IGF-2 Receptor in the Auditory Cortex Improves the Precision of Recent Fear Memories and Maintains Detailed Remote Fear Memories Over Time
| Autor: | Francesca Stabile, Eugenio Manassero, Benedetto Sacchetti, Luisella Milano, Annamaria Renna, Giulia Concina |
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| Rok vydání: | 2021 |
| Předmět: |
Auditory Cortex
Male Memory Long-Term Cognitive Neuroscience Fear Engram Traumatic memories Auditory cortex Receptor IGF Type 2 Rats insulin-growth factor II Cellular and Molecular Neuroscience Expression (architecture) Memory auditory cortex fear generalization insulin-growth factor II receptor learning and memory Generalization (learning) Male rats Animals Recent memory Psychology Neuroscience |
| Zdroj: | Cerebral Cortex. 31:5381-5395 |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhab165 |
| Popis: | Traumatic memories may become less precise over time and lead to the development of fear responses to novel stimuli, a process referred to as time-dependent fear generalization. The conditions that cause the growth of fear generalization over time are poorly understood. Here, we found that, in male rats, the level of discrimination at the early time point contributes to determining whether fear generalization will develop with the passage of time or not, suggesting a link between the precision of recent memory and the stability of remote engrams. We also found that the expression of insulin-like growth factor 2 receptor in layer 2/3 of the auditory cortex is linked to the precision of recent memories and to the stability of remote engrams and the development of fear generalization over time. These findings provide new insights on the neural mechanisms that underlie the time-dependent development of fear generalization that may occur over time after a traumatic event. |
| Databáze: | OpenAIRE |
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