Insulin Resistance and the Risk of Stroke and Stroke Subtypes in the Nondiabetic Elderly

Autor: Peter J. Koudstaal, M. Arfan Ikram, Albert Hofman, Monique M.B. Breteler, Renske G. Wieberdink, Jacqueline C.M. Witteman
Přispěvatelé: Neurology, Epidemiology, Radiology & Nuclear Medicine
Rok vydání: 2012
Předmět:
Male
Brain Stem Infarctions
Epidemiology
metabolism [Stroke]
epidemiology [Cerebral Hemorrhage]
metabolism [Cerebral Infarction]
Body Mass Index
Cohort Studies
Rotterdam Study
Risk Factors
Surveys and Questionnaires
Prevalence
Insulin
epidemiology [Cerebral Infarction]
Stroke
metabolism [Cerebral Hemorrhage]
etiology [Stroke]
Netherlands
Metabolic Syndrome
education.field_of_study
epidemiology [Metabolic Syndrome]
Cerebral infarction
Cerebral Infarction
Fasting
Middle Aged
Female
epidemiology [Stroke]
metabolism [Brain Stem Infarctions]
medicine.medical_specialty
Population
Risk Assessment
Insulin resistance
SDG 3 - Good Health and Well-being
Internal medicine
Diabetes mellitus
medicine
Humans
cardiovascular diseases
ddc:610
Risk factor
education
epidemiology [Brain Stem Infarctions]
Aged
Cerebral Hemorrhage
Proportional Hazards Models
Intracerebral hemorrhage
business.industry
epidemiology [Netherlands]
medicine.disease
Health Surveys
blood [Insulin]
Endocrinology
Insulin Resistance
business
Follow-Up Studies
Zdroj: American journal of epidemiology 176(8), 699-707 (2012). doi:10.1093/aje/kws149
American Journal of Epidemiology, 176(8), 699-707. Oxford University Press
ISSN: 1476-6256
0002-9262
DOI: 10.1093/aje/kws149
Popis: Insulin resistance, which plays a key role in the development of diabetes mellitus, is a putative modifiable risk factor for stroke. The aim of this study was to investigate if markers of insulin resistance were associated with risk of stroke in the general elderly population. This study was part of the large population-based Rotterdam Study and included 5,234 participants who were aged 55 years or older and stroke free and diabetes free at baseline (1997-2001). Fasting insulin levels and homeostasis model assessment for insulin resistance were used as markers for insulin resistance. Cox regression was used to determine associations between insulin resistance markers and stroke risk, adjusted for age, sex, and potential confounders. During 42,806 person-years of follow-up (median: 8.6 years), 366 first-ever strokes occurred, of which 225 were cerebral infarctions, 42 were intracerebral hemorrhages, and 99 were unspecified strokes. Fasting insulin levels were not associated with risk of any stroke, cerebral infarction, or intracerebral hemorrhage. Homeostasis model assessment for insulin resistance, which almost perfectly correlated with fasting insulin levels, was also not associated with risk of stroke or stroke subtypes. In conclusion, in this population-based cohort study among nondiabetic elderly, insulin resistance markers were not associated with risk of stroke or any of its subtypes.
Databáze: OpenAIRE
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