Poly(Ethylene Glycol)-Based Backbones with High Peptide Loading Capacities
| Autor: | Jean-Noel Marsat, Tom Flahive, Annachiara Mitrugno, Aoife O'Connor, Niamh Moran, David J. Brayden, Marc Devocelle |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Blood Platelets
Azides Polymers Allyl glycidyl ether poly(allyl glycidyl ether) Pharmaceutical Science Peptide Conjugated system loading capacity thiol-ene conjugation Article Polyethylene Glycols Analytical Chemistry lcsh:QD241-441 chemistry.chemical_compound Blood platelets lcsh:Organic chemistry Amide Drug Discovery Polymer chemistry Humans Sulfhydryl Compounds peptide-polymer conjugates Amino Acids Physical and Theoretical Chemistry chemistry.chemical_classification Chemistry Polyethylene glycols Organic Chemistry Polymer Sulfhydryl compounds Peptide-polymer conjugates Epoxy compounds Cycloaddition Poly(allyl glycidyl ether) Thiol-ene conjugation Chemistry (miscellaneous) Alkynes Loading capacity Amino acids Epoxy Compounds Molecular Medicine Peptides Ethylene glycol Conjugate |
| Zdroj: | Molecules, Vol 19, Iss 11, Pp 17559-17577 (2014) Molecules Volume 19 Issue 11 Pages 17559-17577 |
| ISSN: | 1420-3049 |
| Popis: | Polymer-peptide conjugates are a promising class of compounds, where polymers can be used to overcome some of the limitations associated with peptides intended for therapeutic and/or diagnostic applications. Linear polymers such as poly(ethylene glycol) can be conjugated through terminal moieties and have therefore limited loading capacities. In this research, functionalised linear poly(ethylene glycol)s are utilised for peptide conjugation, to increase their potential loading capacities. These poly(ethylene glycol) derivatives are conjugated to peptide sequences containing representative side-chain functionalised amino acids, using different conjugation chemistries, including copper-catalysed azide-alkyne cycloaddition, amide coupling and thiol-ene reactions. Conjugation of a sequence containing the RGD motif to poly(allyl glycidyl ether) by the thiol-ene reaction, provided a conjugate which could be used in platelet adhesion studies. Health Research Board Science Foundation Ireland |
| Databáze: | OpenAIRE |
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