Physical key properties of antibiotic-free, PLGA/HPMC-based in-situ forming implants for local periodontitis treatment
| Autor: | Elisabeth Delcourt-Debruyne, T. Rongthong, Florence Siepmann, M. Lizambard, Juergen Siepmann, Kevimy Agossa |
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| Přispěvatelé: | Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 (MBLC - ADDS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille) |
| Rok vydání: | 2017 |
| Předmět: |
In-situ forming implant
Gingival and periodontal pocket medicine.drug_class [SDV]Life Sciences [q-bio] Antibiotics Pharmaceutical Science Dentistry Mechanical properties 02 engineering and technology Tooth brushing 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Hypromellose Derivatives Antiseptic Polylactic Acid-Polyglycolic Acid Copolymer medicine Humans Lactic Acid Periodontitis Drug Implants business.industry Chlorhexidine PLGA Adhesiveness Periodontitis Local controlled drug release 030206 dentistry 021001 nanoscience & nanotechnology medicine.disease chemistry Anti-Infective Agents Local Stress Mechanical Swelling medicine.symptom 0210 nano-technology business Polyglycolic Acid medicine.drug |
| Zdroj: | International Journal of Pharmaceutics International Journal of Pharmaceutics, 2017, International Journal of Pharmaceutics, 521, pp.282-293. ⟨10.1016/j.ijpharm.2017.02.039⟩ |
| ISSN: | 1873-3476 0378-5173 |
| DOI: | 10.1016/j.ijpharm.2017.02.039⟩ |
| Popis: | International audience; In-situ forming implants (ISFI) offer an interesting potential for the treatment of periodontitis, allowing for time-controlled drug release directly at the site of action (which is difficult to reach). For this purpose, ISFI loaded with antibiotics have been reported in the literature. But the use of antibiotic drugs at low doses over prolonged periods of time can lead to the development of bacterial resistances. This risk should be avoided. The aim of this study was to develop a novel type of in-situ forming implants, loaded with the antiseptic drug chlorhexidine. Special emphasis was placed on the physical properties of the systems, assuring a reliable residence time in the periodontal pockets of patients suffering from periodontitis. In particular, the risk of premature, accidental loss of the formulations due to mechanical stress (e.g. during tooth brushing and chewing) was to be reduced. Two commercially available drug products for local periodontitis treatment were studied for reasons of comparison: Chlo-site and Parocline. The syringeability and swelling behavior of the formulations were investigated, and the hardness, springiness, resilience and “stickiness” of the systems determined using extracted human teeth. Interestingly, the novel in-situ forming implants, based on PLGA/HPMC and being free of antibiotics, exhibit highly promising physical key properties: They are intensively sticking to teeth’ surfaces and provide adequate mechanical strength to assure reliable and prolonged residence times in periodontal pockets. In contrast, the commercial drug products showed limited adhesion and either rapidly shrank (Chlo-site), or substantially swelled and were mechanically very weak (Parocline). |
| Databáze: | OpenAIRE |
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