Activation of the acute inflammatory phase response in idiopathic nephrotic syndrome: association with clinicopathological phenotypes and with response to corticosteroids
| Autor: | Cristina Martínez, Elias Jatem, Mercedes López López, Alfons Segarra, Álvaro Madrid, Neus Roca |
|---|---|
| Přispěvatelé: | Institut Català de la Salut, [Roca N] Paediatric Nephrology Department, Hospital Universitari de Vic, Universitat de Vic, Barcelona, Spain. [Martinez C] Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Jatem E] Nephrology Department, Hospital Universitario Arnau de Vilanova, Lleida, Spain. [Madrid A] Paediatric Nephrology Department, Hospital Sant Joan de Déu Barcelona, Barcelona, Spain. [Lopez M] Servei de Nefrologia Pediàtrica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Segarra A] Institut de Recerca Biomèdica August Pi i Sunyer, Barcelona, Spain. Nephrology Department, Hospital Universitario Arnau de Vilanova, Lleida, Spain, Vall d'Hebron Barcelona Hospital Campus |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos [FENÓMENOS Y PROCESOS] 030232 urology & nephrology Antiinflamatoris - Ús terapèutic enfermedades urogenitales masculinas::enfermedades urológicas::enfermedades renales::nefrosis::síndrome nefrótico [ENFERMEDADES] Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores] 030204 cardiovascular system & hematology Male Urogenital Diseases::Urologic Diseases::Kidney Diseases::Nephrosis::Nephrotic Syndrome [DISEASES] urologic and male genital diseases Other subheadings::Other subheadings::/drug therapy [Other subheadings] Gastroenterology 03 medical and health sciences 0302 clinical medicine Focal segmental glomerulosclerosis Membranous nephropathy Internal medicine Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance [PHENOMENA AND PROCESSES] medicine Minimal change disease AcademicSubjects/MED00340 Resistència als medicaments acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antiinflamatorios [COMPUESTOS QUÍMICOS Y DROGAS] Transplantation Proteinuria biology nephrotic syndrome business.industry C-reactive protein Glomerulosclerosis Original Articles medicine.disease minimal change disease SuPAR Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Anti-Inflammatory Agents [CHEMICALS AND DRUGS] inflammation Nephrology biology.protein biomarker medicine.symptom business Nephrotic syndrome glomerulosclerosis Ronyons - Malalties - Tractament |
| Zdroj: | Scientia Clinical Kidney Journal |
| Popis: | Background Data on the activation of the acute inflammatory response and its clinicopathological associations in idiopathic nephrotic syndrome (INS) are scarce and discordant. Objective To analyse the associations between the activation of the inflammatory response, the clinicopathological characteristics of disease and the response to treatment with steroids in patients with INS. Methods A total of 101 patients with INS due to minimal change disease (MCD; n = 44), focal segmental glomerulosclerosis (FSGS; n = 33) and membranous nephropathy (MN; n = 24) and 50 healthy controls were included. At diagnosis, we measured the levels of haemopexin (Hx), haptoglobin (Hgl), interleukin-6 (IL-6), soluble urokinase-type plasminogen activator receptor (suPAR), tumour necrosis factor-α (TNF-α), soluble IL-1 receptor, interferon-γ and C-reactive protein. We analysed their clinicopathological associations. In MCD and FSGS patients, we determined the association between the levels of these variables and steroid resistance. Results The levels of Hx, Hgl, TNF-α, suPAR and IL-6 were higher in patients with INS than in healthy controls, and were not associated with proteinuria, estimated glomerular filtration rate or serum albumin. In MCD and FSGS patients, Hx, Hgl, IL-6 and TNF-α levels were similar and significantly higher than in MN patients. In patients with MCD and FSGS, multivariate analyses identified FSGS and the levels of Hx, Hgl or IL-6 as independent predictors of steroid resistance. Conclusions The activation of the inflammatory response in patients with INS is heterogeneous and more prevalent in MCD or FSGS patients than in those with MN. In MCD and FSGS, elevated levels of Hx, Hgl or IL-6 are independently associated with steroid resistance. |
| Databáze: | OpenAIRE |
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