Potential Effect of COVID-19 on Maternal and Infant Outcome: Lesson From SARS
| Autor: | Xiaoxue Han, Ruiman Li, Yiliang Wang, Yun Wang, Jiazhuo Ye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) viruses Review medicine.disease_cause Pandemic medicine skin and connective tissue diseases Coronavirus Pregnancy Transmission (medicine) business.industry SARS-CoV-2 Potential effect fungi lcsh:RJ1-570 Outbreak virus diseases COVID-19 infant outcome SARS-CoV lcsh:Pediatrics medicine.disease maternal outcome body regions Pneumonia Pediatrics Perinatology and Child Health business |
| Zdroj: | Frontiers in Pediatrics, Vol 8 (2020) Frontiers in Pediatrics |
| ISSN: | 2296-2360 |
| DOI: | 10.3389/fped.2020.00511/full |
| Popis: | The coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is highly infectious and its ongoing outbreak has been declared a global pandemic by the WHO. Pregnant women are susceptible to respiratory pathogens and the development of severe pneumonia, suggesting the urgent need to assess the potential maternal and infant outcome of pregnancy with COVID-19. The intrauterine vertical transmission potential of SARS-CoV-2 also remains controversial. Herein, we discuss the potential effect of COVID-19 on maternal and infant outcomes based on current studies, including those published in Chinese, in a total of 80 mothers with COVID-19 and 80 infants. We also comprehensively explored the mother-to-child transmission routes of SARS-CoV-2, in particular the route of intrauterine vertical transmission. Given SARS-CoV-2 is a sister to SARS-CoV, of the SARS-related coronavirus species, we made a comprehensive comparison between them to learn from experiences with SARS. Although there is no evidence supporting the intrauterine vertical transmission of SARS-CoV-2, our comprehensive analysis suggests that the adverse maternal and infant outcomes caused by COVID-19 cannot be underestimated. Further, we speculated that the inconsistency between nucleic acids and serological characteristics IgM to SARS-CoV-2 of infants' specimens may be caused by the disruption of the amniotic barrier by the inflammatory factors induced by SARS-CoV-2 infection. Our review is beneficial to understand the effect of SARS-CoV-2 on maternal and infant outcomes. |
| Databáze: | OpenAIRE |
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